{"id":57540,"date":"2026-03-05T01:20:04","date_gmt":"2026-03-05T00:20:04","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/03\/05\/targeting-synovial-fibroblast-kca1-1-channels-in-rheumatoid-arthritis\/"},"modified":"2026-03-05T01:20:04","modified_gmt":"2026-03-05T00:20:04","slug":"targeting-synovial-fibroblast-kca1-1-channels-in-rheumatoid-arthritis","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/03\/05\/targeting-synovial-fibroblast-kca1-1-channels-in-rheumatoid-arthritis\/","title":{"rendered":"Targeting synovial fibroblast KCa1.1 channels in rheumatoid arthritis"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2026 Mar 3;100:102747. doi: 10.1016\/j.coi.2026.102747. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Fibroblast-like synoviocytes (FLS) play major roles in the pathogenesis of rheumatoid arthritis (RA). Human and rat FLS express the KCa1.1 channel (BK, Maxi-K, Slo1, and KCNMA1) as their major potassium channel at the plasma membrane. Reducing the expression or function of this channel inhibits pathogenic functions of FLS in vitro and stops disease progression in rat models of RA. However, KCa1.1 is ubiquitously expressed, leading to severe side effects. KCa1.1, however, remains a viable therapeutic target as its \u03b1 subunits can be co-expressed with \u03b2 and \u03b3 regulatory subunits, which alter the biophysical and pharmacological fingerprints of the channel and have a restricted tissue distribution. Highly invasive RA-FLS preferentially express KCa1.1 \u03b1\u03b23, whereas less invasive FLS express KCa1.1 \u03b1\u03b21. The knockdown of \u03b23, but not \u03b21, reduces the invasive capacity of RA-FLS. Development of a selective blocker of KCa1.1 \u03b1\u03b23 might be of interest as a potential FLS-targeted therapeutic for RA.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41780097\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20260304191954&amp;v=2.19.0.post6+133c1fe\">41780097<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2026.102747\">10.1016\/j.coi.2026.102747<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2026 Mar 3;100:102747. doi: 10.1016\/j.coi.2026.102747. Online ahead of print. ABSTRACT Fibroblast-like synoviocytes (FLS) play major roles in the pathogenesis of rheumatoid arthritis (RA). Human and rat FLS express the KCa1.1 channel (BK, Maxi-K, Slo1, and KCNMA1) as their major potassium channel at the plasma membrane. Reducing the expression or function of this &#8230; <a title=\"Targeting synovial fibroblast KCa1.1 channels in rheumatoid arthritis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/05\/targeting-synovial-fibroblast-kca1-1-channels-in-rheumatoid-arthritis\/\" aria-label=\"Read more about Targeting synovial fibroblast KCa1.1 channels in rheumatoid arthritis\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-57540","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/57540","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=57540"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/57540\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=57540"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=57540"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=57540"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}