{"id":57541,"date":"2026-03-05T01:20:04","date_gmt":"2026-03-05T00:20:04","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/03\/05\/beyond-ion-flux-the-potassium-channel-kv1-3-and-its-regulatory-function-in-neutrophils\/"},"modified":"2026-03-05T01:20:04","modified_gmt":"2026-03-05T00:20:04","slug":"beyond-ion-flux-the-potassium-channel-kv1-3-and-its-regulatory-function-in-neutrophils","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/03\/05\/beyond-ion-flux-the-potassium-channel-kv1-3-and-its-regulatory-function-in-neutrophils\/","title":{"rendered":"Beyond ion flux: the potassium channel KV1.3 and its regulatory function in neutrophils"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2026 Mar 3;100:102750. doi: 10.1016\/j.coi.2026.102750. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The voltage-gated potassium channel K<sub>V<\/sub>1.3 (KCNA3) is a critical ion channel regulating membrane potential in immune cells, facilitating sustained calcium influx and activating downstream signaling events. Besides its canonical role as an ion channel, K<sub>V<\/sub>1.3 has been postulated to exert additional functions in immune biology. In this review, we summarize how recruitment of K<sub>V<\/sub>1.3 into cholesterol-rich lipid raft microdomains positions K<sub>V<\/sub>1.3 as a scaffold (demonstrated directly in T cells and microglia) for kinases, adaptor proteins, and transcriptional regulators, integrating ion flux with receptor signaling pathways that control adhesion, migration, and damage-associated molecular pattern release in immune cells. We further discuss how these observations may explain recent findings in K<sub>V<\/sub>1.3 function in neutrophil biology and how its inhibition may offer a refined strategy to selectively modulate immune responses in sterile inflammation and beyond. This highlights the need for neutrophil-specific K<sub>V<\/sub>1.3 interactomics and spatiotemporal raft\/adhesion nanodomain mapping.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41780096\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20260304191954&amp;v=2.19.0.post6+133c1fe\">41780096<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2026.102750\">10.1016\/j.coi.2026.102750<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2026 Mar 3;100:102750. doi: 10.1016\/j.coi.2026.102750. Online ahead of print. ABSTRACT The voltage-gated potassium channel KV1.3 (KCNA3) is a critical ion channel regulating membrane potential in immune cells, facilitating sustained calcium influx and activating downstream signaling events. Besides its canonical role as an ion channel, KV1.3 has been postulated to exert additional functions &#8230; <a title=\"Beyond ion flux: the potassium channel KV1.3 and its regulatory function in neutrophils\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/05\/beyond-ion-flux-the-potassium-channel-kv1-3-and-its-regulatory-function-in-neutrophils\/\" aria-label=\"Read more about Beyond ion flux: the potassium channel KV1.3 and its regulatory function in neutrophils\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-57541","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/57541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=57541"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/57541\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=57541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=57541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=57541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}