{"id":59257,"date":"2026-03-19T20:43:13","date_gmt":"2026-03-19T19:43:13","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/03\/19\/foxm1-specific-tcr-engineered-t-cells-target-non-small-cell-lung-cancer\/"},"modified":"2026-03-19T20:43:13","modified_gmt":"2026-03-19T19:43:13","slug":"foxm1-specific-tcr-engineered-t-cells-target-non-small-cell-lung-cancer","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/03\/19\/foxm1-specific-tcr-engineered-t-cells-target-non-small-cell-lung-cancer\/","title":{"rendered":"FOXM1-specific TCR-engineered T cells target non-small cell lung cancer"},"content":{"rendered":"<div>\n<p><b>Cancer Immunol Res<\/b>. 2026 Mar 19. doi: 10.1158\/2326-6066.CIR-25-0605. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>FOXM1 is highly expressed in various cancer types and considered a key driver of cancer progression. Accordingly, we evaluated the immunogenicity of FOXM1 and investigated the feasibility of targeting this transcription factor using T cell receptor (TCR) engineering. We identified epitopes derived from FOXM1 which were immunogenic on HLA-A*02:01, HLA-A*24:02, and HLA-A*23:01, endogenously-processed and presented, and resulted in T cell activation and cytotoxic T cell responses. Following the generation of TCR-T cells, sensitivity and specificity were confirmed by peptide dose-response and X-scan, respectively. Most importantly, adoptive transfer of TCR engineered T cells led to a significant reduction in tumor growth, as well as significantly prolonged survival in a tumor-bearing immunocompromised murine model. Our studies confirm the immunogenicity of FOXM1 and feasibility of targeting this antigen using TCR-engineering.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41854516\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101614637&amp;ff=20260319154312&amp;v=2.19.0.post6+133c1fe\">41854516<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1158\/2326-6066.CIR-25-0605\">10.1158\/2326-6066.CIR-25-0605<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Cancer Immunol Res. 2026 Mar 19. doi: 10.1158\/2326-6066.CIR-25-0605. Online ahead of print. ABSTRACT FOXM1 is highly expressed in various cancer types and considered a key driver of cancer progression. Accordingly, we evaluated the immunogenicity of FOXM1 and investigated the feasibility of targeting this transcription factor using T cell receptor (TCR) engineering. We identified epitopes derived &#8230; <a title=\"FOXM1-specific TCR-engineered T cells target non-small cell lung cancer\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/19\/foxm1-specific-tcr-engineered-t-cells-target-non-small-cell-lung-cancer\/\" aria-label=\"Read more about FOXM1-specific TCR-engineered T cells target non-small cell lung cancer\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[55,42],"tags":[],"class_list":["post-59257","post","type-post","status-publish","format-standard","hentry","category-cancer-immunology-reserch","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/59257","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=59257"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/59257\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=59257"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=59257"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=59257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}