{"id":59361,"date":"2026-03-22T11:49:19","date_gmt":"2026-03-22T10:49:19","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/03\/22\/macrophage-sirt6-promotes-allergic-airway-inflammation-through-atg3-deacetylation-mediated-autophagy-yuting-lei\/"},"modified":"2026-03-22T11:49:19","modified_gmt":"2026-03-22T10:49:19","slug":"macrophage-sirt6-promotes-allergic-airway-inflammation-through-atg3-deacetylation-mediated-autophagy-yuting-lei","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/03\/22\/macrophage-sirt6-promotes-allergic-airway-inflammation-through-atg3-deacetylation-mediated-autophagy-yuting-lei\/","title":{"rendered":"Macrophage SIRT6 promotes allergic airway inflammation through ATG3 deacetylation-mediated autophagy. Yuting Lei"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 Mar 19:S1933-0219(26)00033-4. doi: 10.1016\/j.mucimm.2026.03.009. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Chronic airway inflammation is a central driver of asthma pathogenesis, in which macrophages play a pivotal role. While autophagy is known to regulate macrophage function, the specific molecular mechanisms linking autophagy to allergic airway inflammation remain unclear. Here, we identify macrophage sirtuin 6 (SIRT6) as a critical regulator of autophagy and allergic inflammation in asthma. SIRT6 expression was elevated in lung tissues and macrophages from asthmatic mice. Myeloid-specific Sirt6 deletion attenuated allergic airway inflammation in asthma murine model. Mechanistically, SIRT6 promoted proinflammatory cytokine expression via autophagy-related 3 (ATG3)-mediated autophagy in macrophages. We further demonstrated that SIRT6 directly bound to ATG3 and deacetylated it at lysine 77 (K77), a modification required for driving the proinflammatory response. Importantly, pharmacological inhibition of SIRT6 with OSS_128167 suppressed macrophage autophagy and alleviated allergic inflammation. Our findings establish SIRT6 as a key promoter of allergic airway inflammation through ATG3 deacetylation and enhanced autophagy in macrophages, highlighting SIRT6 inhibition as a potential novel therapeutic strategy for asthma.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41864241\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260322064918&amp;v=2.19.0.post6+133c1fe\">41864241<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.03.009\">10.1016\/j.mucimm.2026.03.009<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 Mar 19:S1933-0219(26)00033-4. doi: 10.1016\/j.mucimm.2026.03.009. Online ahead of print. ABSTRACT Chronic airway inflammation is a central driver of asthma pathogenesis, in which macrophages play a pivotal role. While autophagy is known to regulate macrophage function, the specific molecular mechanisms linking autophagy to allergic airway inflammation remain unclear. Here, we identify macrophage sirtuin 6 &#8230; <a title=\"Macrophage SIRT6 promotes allergic airway inflammation through ATG3 deacetylation-mediated autophagy. Yuting Lei\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/22\/macrophage-sirt6-promotes-allergic-airway-inflammation-through-atg3-deacetylation-mediated-autophagy-yuting-lei\/\" aria-label=\"Read more about Macrophage SIRT6 promotes allergic airway inflammation through ATG3 deacetylation-mediated autophagy. Yuting Lei\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-59361","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/59361","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=59361"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/59361\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=59361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=59361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=59361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}