{"id":59784,"date":"2026-03-26T12:16:28","date_gmt":"2026-03-26T11:16:28","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/03\/26\/the-value-of-dysregulated-mir-4492-traf6-in-diagnosis-and-prognosis-for-patients-with-community-acquired-pneumonia\/"},"modified":"2026-03-26T12:16:28","modified_gmt":"2026-03-26T11:16:28","slug":"the-value-of-dysregulated-mir-4492-traf6-in-diagnosis-and-prognosis-for-patients-with-community-acquired-pneumonia","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/03\/26\/the-value-of-dysregulated-mir-4492-traf6-in-diagnosis-and-prognosis-for-patients-with-community-acquired-pneumonia\/","title":{"rendered":"The value of dysregulated miR-4492\/TRAF6 in diagnosis and prognosis for patients with community-acquired pneumonia"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Mar 17;215(3):vkag021. doi: 10.1093\/jimmun\/vkag021.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Community-acquired pneumonia (CAP) poses a serious threat to the lives of adults. Differentially expressed miRNAs play a crucial regulatory role in CAP. This study aims to explore the diagnostic and prognostic significance of miR-4492 in CAP and its possible mechanism of action with tumor necrosis factor receptor-associated factor 6 (TRAF6) in human bronchial epithelial cells (HBEpCs). Differentially expressed miRNAs were screened from the GSE196399 dataset, and miR-4492 levels were collected and detected in the serum of CAP patients. The diagnostic and prognostic value of miR-4492 was evaluated using receiver operating characteristic (ROC) curve, Kaplan-Meier survival analysis, and multivariate Cox regression model. miR-4492-TRAF6 interaction was validated via dual-luciferase assays and Pearson correlation. Cell viability and inflammatory factor concentrations were assessed using the CCK-8 assay and ELISA. miR-4492 was downregulated in the serum of CAP patients. ROC analysis demonstrated that miR-4492 distinguished the CAP patients from healthy controls, and its expression was negatively correlated with the CURB-65 score severity. Low miR-4492 level was a predictor of poor prognosis in CAP. TRAF6 was the target gene of miR-4492. LPS inhibited the expression level of miR-4492 and cell viability, and promoted the expression of TRAF6 and inflammation in HBEpCs. Overexpression of miR-4492 enhanced cell viability and suppressed the inflammatory response of HBEpCs, while overexpression of TRAF6 partly reversed the effect of miR-4492. In conclusion, low serum miR-4492 serves as a diagnostic and prognostic biomarker for CAP. miR-4492 mitigated LPS-induced inflammation and cell damage in HBEpCs by targeting TRAF6.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41885008\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260326071627&amp;v=2.19.0.post6+133c1fe\">41885008<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag021\">10.1093\/jimmun\/vkag021<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Mar 17;215(3):vkag021. doi: 10.1093\/jimmun\/vkag021. ABSTRACT Community-acquired pneumonia (CAP) poses a serious threat to the lives of adults. Differentially expressed miRNAs play a crucial regulatory role in CAP. This study aims to explore the diagnostic and prognostic significance of miR-4492 in CAP and its possible mechanism of action with tumor necrosis factor receptor-associated &#8230; <a title=\"The value of dysregulated miR-4492\/TRAF6 in diagnosis and prognosis for patients with community-acquired pneumonia\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/26\/the-value-of-dysregulated-mir-4492-traf6-in-diagnosis-and-prognosis-for-patients-with-community-acquired-pneumonia\/\" aria-label=\"Read more about The value of dysregulated miR-4492\/TRAF6 in diagnosis and prognosis for patients with community-acquired pneumonia\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-59784","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/59784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=59784"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/59784\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=59784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=59784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=59784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}