{"id":59909,"date":"2026-03-29T13:41:04","date_gmt":"2026-03-29T11:41:04","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/03\/29\/redefining-nucleotide-binding-oligomerization-domain-like-receptors-from-immune-sentinels-to-multifunctional-regulators-suhyun-kim\/"},"modified":"2026-03-29T13:41:04","modified_gmt":"2026-03-29T11:41:04","slug":"redefining-nucleotide-binding-oligomerization-domain-like-receptors-from-immune-sentinels-to-multifunctional-regulators-suhyun-kim","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/03\/29\/redefining-nucleotide-binding-oligomerization-domain-like-receptors-from-immune-sentinels-to-multifunctional-regulators-suhyun-kim\/","title":{"rendered":"Redefining nucleotide-binding oligomerization domain-like receptors: from immune sentinels to multifunctional regulators. Suhyun Kim"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2026 Mar 28:S1471-4906(26)00063-3. doi: 10.1016\/j.it.2026.03.004. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are a large family of intracellular pattern recognition receptors primarily involved in innate immunity. Although canonical inflammasome-forming NLRs, such as NLRP3 and NLRC4, and microbial sensors, including NOD1 and NOD2, are well-characterized, the functions of many other NLRs remain poorly understood. This review article addresses this gap by highlighting the critical, context-dependent roles of these less-characterized NLRs beyond pathogen sensing. We classify these NLRs as immune modulators, regulators of autophagy and mitophagy, tissue-specific effectors, and reproductive mediators, expanding the traditional view of NLR functions. Understanding the diverse, context-dependent roles of NLRs across biological systems is essential to fully understand their complex regulatory networks and therapeutic potential, which extends beyond classical inflammasome functions.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41904048\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20260329074103&amp;v=2.19.0.post6+133c1fe\">41904048<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2026.03.004\">10.1016\/j.it.2026.03.004<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2026 Mar 28:S1471-4906(26)00063-3. doi: 10.1016\/j.it.2026.03.004. Online ahead of print. ABSTRACT Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are a large family of intracellular pattern recognition receptors primarily involved in innate immunity. Although canonical inflammasome-forming NLRs, such as NLRP3 and NLRC4, and microbial sensors, including NOD1 and NOD2, are well-characterized, the functions of many other &#8230; <a title=\"Redefining nucleotide-binding oligomerization domain-like receptors: from immune sentinels to multifunctional regulators. Suhyun Kim\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/29\/redefining-nucleotide-binding-oligomerization-domain-like-receptors-from-immune-sentinels-to-multifunctional-regulators-suhyun-kim\/\" aria-label=\"Read more about Redefining nucleotide-binding oligomerization domain-like receptors: from immune sentinels to multifunctional regulators. Suhyun Kim\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-59909","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/59909","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=59909"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/59909\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=59909"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=59909"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=59909"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}