{"id":59912,"date":"2026-03-29T13:41:08","date_gmt":"2026-03-29T11:41:08","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/03\/29\/activation-and-lineage-specific-lag3-expression-dynamics-in-t-cells\/"},"modified":"2026-03-29T13:41:08","modified_gmt":"2026-03-29T11:41:08","slug":"activation-and-lineage-specific-lag3-expression-dynamics-in-t-cells","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/03\/29\/activation-and-lineage-specific-lag3-expression-dynamics-in-t-cells\/","title":{"rendered":"Activation and lineage specific Lag3 expression dynamics in T cells"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Mar 17;215(3):vkag039. doi: 10.1093\/jimmun\/vkag039.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Co-inhibitory receptors are essential checkpoints to restrain excessive T cell activation. While PD1 and CTLA4 have been extensively studied, the biology of lymphocyte activation gene 3 (Lag3), an emerging target for checkpoint blockade immunotherapy, remains less understood. In this study, we show that Lag3, though largely intracellular in resting T cells, exhibits unexpected dynamic cycling even without stimulation. The Lag3 cycling are influenced by lineage and differentiation status, particularly within memory and regulatory T cell subsets. Moreover, Lag3-like cycling patterns were also observed in other co-receptors with stimulatory and inhibitory properties. Mechanistically, endosomal trafficking is important for Lag3 cycling, whereas the cytoplasmic domain of Lag3 appears to be largely dispensable for this process. T cells engaging in Lag3 cycling exhibit a survival and proliferation advantage in both lymphpenic and lymphoreplete conditions. Together, these findings establish Lag3 cycling as a regulated and functionally important process, providing new insights into the biology of Lag3 in T cells.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41903196\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260329074107&amp;v=2.19.0.post6+133c1fe\">41903196<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag039\">10.1093\/jimmun\/vkag039<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Mar 17;215(3):vkag039. doi: 10.1093\/jimmun\/vkag039. ABSTRACT Co-inhibitory receptors are essential checkpoints to restrain excessive T cell activation. While PD1 and CTLA4 have been extensively studied, the biology of lymphocyte activation gene 3 (Lag3), an emerging target for checkpoint blockade immunotherapy, remains less understood. In this study, we show that Lag3, though largely intracellular &#8230; <a title=\"Activation and lineage specific Lag3 expression dynamics in T cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/29\/activation-and-lineage-specific-lag3-expression-dynamics-in-t-cells\/\" aria-label=\"Read more about Activation and lineage specific Lag3 expression dynamics in T cells\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-59912","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/59912","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=59912"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/59912\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=59912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=59912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=59912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}