{"id":60871,"date":"2026-04-11T07:15:12","date_gmt":"2026-04-11T05:15:12","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/04\/11\/the-nox2-nadph-oxidase-regulates-neutrophilic-inflammation-in-the-oral-cavity-shunying-jin\/"},"modified":"2026-04-11T07:15:12","modified_gmt":"2026-04-11T05:15:12","slug":"the-nox2-nadph-oxidase-regulates-neutrophilic-inflammation-in-the-oral-cavity-shunying-jin","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/04\/11\/the-nox2-nadph-oxidase-regulates-neutrophilic-inflammation-in-the-oral-cavity-shunying-jin\/","title":{"rendered":"The Nox2 NADPH oxidase regulates neutrophilic inflammation in the oral cavity. Shunying Jin"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 Apr 8:S1933-0219(26)00039-5. doi: 10.1016\/j.mucimm.2026.04.002. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The leukocyte NADPH oxidase 2 (Nox2) is an important regulator of inflammatory responses, independent of its antimicrobial activity. Inactivating mutations in NOX2 cause chronic granulomatous disease (CGD), a severe immunodeficiency associated with recurrent infections and dysregulated neutrophilic inflammation. Recurrent oral ulcers, stomatitis, gingivitis, and other inflammatory issues affecting the oral mucosa have been observed in patients with CGD; however, the underlying mechanisms are not known. Here, we present evidence that the extensive inflammatory destruction of oral mucosal tissues observed in Nox2-deficient or Cybb<sup>KO<\/sup> mice was not caused by impaired antimicrobial surveillance against oral pathobionts but instead resulted from a cell-intrinsic dysregulation of neutrophil inflammatory responses. Transcriptional and cellular profiling of oral tissues isolated from wild-type and Cybb<sup>KO<\/sup> mice showed a dominant neutrophil signature, which was accompanied by a significant upregulation of several bone-resorbing, tissue-degrading inflammatory cytokines and a reduced expression of nuclear factor erythroid 2-related factor 2 (Nrf2) regulated genes. Mechanistically, hyperinflammatory responses were mitigated by restoring Nrf2 transcriptional activity using a synthetic agonist. Thus, our studies show that Nox2 oxidase and derivative reactive oxygen species generation are crucial for balanced recruitment and cell-intrinsic regulation of neutrophil inflammatory responses within oral tissues in an Nrf2-dependent manner.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41962901\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260411011511&amp;v=2.19.0.post6+133c1fe\">41962901<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.04.002\">10.1016\/j.mucimm.2026.04.002<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 Apr 8:S1933-0219(26)00039-5. doi: 10.1016\/j.mucimm.2026.04.002. Online ahead of print. ABSTRACT The leukocyte NADPH oxidase 2 (Nox2) is an important regulator of inflammatory responses, independent of its antimicrobial activity. Inactivating mutations in NOX2 cause chronic granulomatous disease (CGD), a severe immunodeficiency associated with recurrent infections and dysregulated neutrophilic inflammation. Recurrent oral ulcers, stomatitis, gingivitis, &#8230; <a title=\"The Nox2 NADPH oxidase regulates neutrophilic inflammation in the oral cavity. Shunying Jin\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/11\/the-nox2-nadph-oxidase-regulates-neutrophilic-inflammation-in-the-oral-cavity-shunying-jin\/\" aria-label=\"Read more about The Nox2 NADPH oxidase regulates neutrophilic inflammation in the oral cavity. Shunying Jin\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-60871","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/60871","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=60871"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/60871\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=60871"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=60871"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=60871"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}