{"id":61024,"date":"2026-04-14T07:19:06","date_gmt":"2026-04-14T05:19:06","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/04\/14\/cd160-competent-ilc2-are-crucial-for-the-ejection-of-intestinal-helminths-by-the-innate-immune-system-lennart-heepmann\/"},"modified":"2026-04-14T07:19:06","modified_gmt":"2026-04-14T05:19:06","slug":"cd160-competent-ilc2-are-crucial-for-the-ejection-of-intestinal-helminths-by-the-innate-immune-system-lennart-heepmann","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/04\/14\/cd160-competent-ilc2-are-crucial-for-the-ejection-of-intestinal-helminths-by-the-innate-immune-system-lennart-heepmann\/","title":{"rendered":"CD160-competent ILC2 are crucial for the ejection of intestinal helminths by the innate immune system. Lennart Heepmann"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 Apr 11:S1933-0219(26)00042-5. doi: 10.1016\/j.mucimm.2026.04.005. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>1.6 billion people are currently infected with parasitic worms. Group 2 innate lymphoid cells (ILC2) play a central role in promoting the protective type 2 immunity against these parasites. Here we show that a subpopulation of intestinal ILC2 express the immune checkpoint molecule CD160 in mice infected with the parasitic nematode Strongyloides ratti. CD160<sup>+<\/sup> ILC2 represented a distinct ST2<sup>&#8211;<\/sup>IL-17RB<sup>+<\/sup>Ki-67<sup>+<\/sup> subset that expanded in vivo during S. ratti infection. By contrast, CD160<sup>&#8211;<\/sup> ILC2 were ST2<sup>+<\/sup>IL-17RB<sup>&#8211;<\/sup>Ki-67<sup>&#8211;<\/sup> and represented the dominant producers of type 2 cytokines. Upon in vitro stimulation, sorted CD160<sup>+<\/sup> ILC2 progressively lost CD160 expression and acquired cytokine-producing capacity. While CD160-competent RAG KO mice efficiently controlled S. ratti infection with less than 1% of the infective dose remaining by day 10 post-infection, CD160-deficient RAG KO mice failed to expand intestinal ILC2, failed to activate mucosal mast cells and retained high intestinal worm burden for nearly 100 days. Adoptive transfer of CD160-competent ILC2 into S. ratti-infected CD160-deficient RAG KO mice partially restored mast cell activation and reduced intestinal worm burden by 50%. Collectively, these findings identify CD160 expression as a critical checkpoint in the development and expansion of fully functional ILC2 required for effective immunity against intestinal helminth infection.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41974253\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260414011905&amp;v=2.19.0.post6+133c1fe\">41974253<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.04.005\">10.1016\/j.mucimm.2026.04.005<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 Apr 11:S1933-0219(26)00042-5. doi: 10.1016\/j.mucimm.2026.04.005. Online ahead of print. ABSTRACT 1.6 billion people are currently infected with parasitic worms. Group 2 innate lymphoid cells (ILC2) play a central role in promoting the protective type 2 immunity against these parasites. Here we show that a subpopulation of intestinal ILC2 express the immune checkpoint molecule &#8230; <a title=\"CD160-competent ILC2 are crucial for the ejection of intestinal helminths by the innate immune system. Lennart Heepmann\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/14\/cd160-competent-ilc2-are-crucial-for-the-ejection-of-intestinal-helminths-by-the-innate-immune-system-lennart-heepmann\/\" aria-label=\"Read more about CD160-competent ILC2 are crucial for the ejection of intestinal helminths by the innate immune system. Lennart Heepmann\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-61024","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/61024","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=61024"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/61024\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=61024"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=61024"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=61024"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}