{"id":61919,"date":"2026-04-16T19:09:57","date_gmt":"2026-04-16T17:09:57","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/04\/16\/cd8-t-cells-contribute-to-arterial-aging-in-mice\/"},"modified":"2026-04-16T19:09:57","modified_gmt":"2026-04-16T17:09:57","slug":"cd8-t-cells-contribute-to-arterial-aging-in-mice","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/04\/16\/cd8-t-cells-contribute-to-arterial-aging-in-mice\/","title":{"rendered":"CD8+ T cells contribute to arterial aging in mice"},"content":{"rendered":"
\n

J Immunol<\/b>. 2026 Apr 15;215(4):vkag060. doi: 10.1093\/jimmun\/vkag060.<\/p>\n

ABSTRACT<\/b><\/p>\n

We have previously reported that T cells accumulate in the arteries of old mice and mechanistically contribute to the development of age-related arterial dysfunction. However, the specific T cell subtype that is the primary contributor to arterial aging is unknown. There is substantial evidence that CD8+ T cells are more susceptible to the effects of aging compared with their CD4+ counterparts. We hypothesized that CD8+ T cell-specific depletion would ameliorate large-artery stiffness and augment endothelium-dependent dilation in old mice but not in young mice. We observed that old mice exhibited a greater accumulation of CD8+, but not CD4+, T cells in the aorta and mesentery compared with their young counterparts. Further, pharmacological depletion of CD8+, but not CD4+, T cells resulted in lower aortic stiffness and blunted aortic collagen. In addition, old CD8+, but not CD4+, depleted mice demonstrated augmented endothelium-dependent dilation via greater nitric oxide bioavailability. These data indicate that CD8+ T cells are the specific T cell subtype that contributes to age-related arterial dysfunction.<\/p>\n

PMID:41986876<\/a> | DOI:10.1093\/jimmun\/vkag060<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

J Immunol. 2026 Apr 15;215(4):vkag060. doi: 10.1093\/jimmun\/vkag060. ABSTRACT We have previously reported that T cells accumulate in the arteries of old mice and mechanistically contribute to the development of age-related arterial dysfunction. However, the specific T cell subtype that is the primary contributor to arterial aging is unknown. There is substantial evidence that CD8+ T … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-61919","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/61919","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=61919"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/61919\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=61919"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=61919"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=61919"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}