{"id":62044,"date":"2026-04-19T19:08:15","date_gmt":"2026-04-19T17:08:15","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/04\/19\/immunosenescence-and-human-healthspan-lessons-from-centenarians\/"},"modified":"2026-04-19T19:08:15","modified_gmt":"2026-04-19T17:08:15","slug":"immunosenescence-and-human-healthspan-lessons-from-centenarians","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/04\/19\/immunosenescence-and-human-healthspan-lessons-from-centenarians\/","title":{"rendered":"Immunosenescence and human healthspan. Lessons from centenarians"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2026 Apr 16;100:102777. doi: 10.1016\/j.coi.2026.102777. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Immunosenescence is a multidimensional remodeling of immunity, characterized by inflammaging, cellular senescence, T-cell exhaustion, and thymic involution, that raises infection and disease risk with age. Emerging evidence, notably from centenarians, shows immune aging follows divergent trajectories: rather than a uniform decline, extreme longevity often reflects adaptive remodeling and a maintained immune equilibrium. Centenarian immune profiles are characterized by selective retention of na\u00efve T cells, expansion of cytotoxic CD4+ and CD8+ subsets, tightly regulated inflammatory signaling, and systemic protective mechanisms such as enhanced oxidative-stress resistance, preserved epigenetic regulation, and extracellular vesicle-mediated T-cell modulation. Progress is constrained by cohort heterogeneity and limited longitudinal, harmonized multi-omic data; addressing these gaps could produce biological-age biomarkers and inform immunometabolic or senotherapeutic strategies to extend healthspan. In this narrative review, we describe that immunosenescence should be viewed as a trajectory-dependent process in which balanced immune function, not mere preservation of youthful markers, determines resilience and healthy aging.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42000176\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20260419130814&amp;v=2.19.0.post6+133c1fe\">42000176<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2026.102777\">10.1016\/j.coi.2026.102777<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2026 Apr 16;100:102777. doi: 10.1016\/j.coi.2026.102777. Online ahead of print. ABSTRACT Immunosenescence is a multidimensional remodeling of immunity, characterized by inflammaging, cellular senescence, T-cell exhaustion, and thymic involution, that raises infection and disease risk with age. Emerging evidence, notably from centenarians, shows immune aging follows divergent trajectories: rather than a uniform decline, extreme &#8230; <a title=\"Immunosenescence and human healthspan. Lessons from centenarians\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/19\/immunosenescence-and-human-healthspan-lessons-from-centenarians\/\" aria-label=\"Read more about Immunosenescence and human healthspan. Lessons from centenarians\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-62044","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/62044","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=62044"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/62044\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=62044"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=62044"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=62044"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}