{"id":62119,"date":"2026-04-20T19:23:25","date_gmt":"2026-04-20T17:23:25","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/the-dual-role-of-peritoneal-cavity-b-cells-in-the-activation-of-antitumor-t-cells\/"},"modified":"2026-04-20T19:23:25","modified_gmt":"2026-04-20T17:23:25","slug":"the-dual-role-of-peritoneal-cavity-b-cells-in-the-activation-of-antitumor-t-cells","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/the-dual-role-of-peritoneal-cavity-b-cells-in-the-activation-of-antitumor-t-cells\/","title":{"rendered":"The dual role of peritoneal cavity B cells in the activation of antitumor T cells"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Apr 15;215(4):vkag058. doi: 10.1093\/jimmun\/vkag058.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Peritoneal cavity (PerC) B cells can be classified into distinct subpopulations; however, their differential antigen-presenting capabilities and roles in antitumor immune responses remain largely unexplored. This study aimed to elucidate the properties of PerC B cell subpopulations in antitumor immune responses by using ovalbumin (OVA) peptides as neoantigen mimics and employing OT-I mice, which express a transgenic T cell receptor specific to OVA peptides. We found that OVA-pulsed PerC B cells effectively stimulated CD8+ T cell proliferation, although their antigen-presenting capacity was lower than that of splenic B cells. Subpopulation analysis revealed that CD11b+CD80+ and CD11b-CD80+ B cells produced high levels of interleukin 10 (IL-10), contributing to immunosuppressive effects. Blocking IL-10 significantly enhanced T cell proliferation and cytotoxicity, whereas PD-L1\/PD-L2 blockade had no significant impact. The CD8+ T cell response in OT-I mice, stimulated by bone marrow-derived dendritic cells (BMDCs) that had phagocytosed OVA, was dose-dependently suppressed by OVA-pulsed peritoneal B cells. In an in vivo tumor model using Rag2-\/- mice, co-administration of OVA-pulsed PerC B cells transiently suppressed tumor growth at lower B: T ratios but promoted tumor progression at higher B: T ratios. IL-10 knockdown in PerC B cells further enhanced tumor suppression. These findings suggest that PerC B cells exhibit a dual role in antitumor immunity, modulating CD8+ T cell responses in a density-dependent manner. While they can function as antigen-presenting cells to enhance T cell activation, their IL-10-mediated immunosuppressive properties can dampen antitumor responses. Understanding this balance may provide insights for optimizing B cell-based immunotherapies.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42001519\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260420132324&amp;v=2.19.0.post6+133c1fe\">42001519<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag058\">10.1093\/jimmun\/vkag058<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Apr 15;215(4):vkag058. doi: 10.1093\/jimmun\/vkag058. ABSTRACT Peritoneal cavity (PerC) B cells can be classified into distinct subpopulations; however, their differential antigen-presenting capabilities and roles in antitumor immune responses remain largely unexplored. This study aimed to elucidate the properties of PerC B cell subpopulations in antitumor immune responses by using ovalbumin (OVA) peptides as &#8230; <a title=\"The dual role of peritoneal cavity B cells in the activation of antitumor T cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/the-dual-role-of-peritoneal-cavity-b-cells-in-the-activation-of-antitumor-t-cells\/\" aria-label=\"Read more about The dual role of peritoneal cavity B cells in the activation of antitumor T cells\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-62119","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/62119","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=62119"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/62119\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=62119"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=62119"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=62119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}