{"id":62125,"date":"2026-04-20T19:23:26","date_gmt":"2026-04-20T17:23:26","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/loss-of-the-actin-remodeling-protein-flightless-1-impairs-cd8-and-regulatory-t-cell-function\/"},"modified":"2026-04-20T19:23:26","modified_gmt":"2026-04-20T17:23:26","slug":"loss-of-the-actin-remodeling-protein-flightless-1-impairs-cd8-and-regulatory-t-cell-function","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/loss-of-the-actin-remodeling-protein-flightless-1-impairs-cd8-and-regulatory-t-cell-function\/","title":{"rendered":"Loss of the actin remodeling protein Flightless-1 impairs CD8 and regulatory T cell function"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Apr 15;215(4):vkag019. doi: 10.1093\/jimmun\/vkag019.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>T cell immunity depends on the precise coordination of signaling networks with actin cytoskeleton remodeling, yet the molecular regulators of these processes remain incompletely defined. Flightless-1 (FLII) is a gelsolin-family actin regulator with unique leucine-rich repeats that can couple cytoskeletal dynamics to diverse signaling pathways. Here, using conditional knockout mice, we identify essential roles for FLII in both CD8+ and regulatory T cells. Loss of FLII in CD8+ T cells caused a profound loss of naive cells from the spleen, impaired CCR7-dependent migration, and defective accumulation in the lung parenchyma during antigen-specific responses to respiratory vesicular stomatitis virus infection, despite largely preserved activation, effector differentiation, and cytotoxic function. FLII-deficient Foxp3+ regulatory T cells maintained normal numbers but exhibited diminished CD25 expression, defective interleukin (IL)-2 signaling and failed to restrain spontaneous, tissue-specific autoimmunity. These findings identify FLII as a critical and previously unrecognized orchestrator of T cell trafficking and immune regulation, which may link chemokine receptor signaling to actin remodeling and is essential for proper T cell migration and function.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42001513\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260420132324&amp;v=2.19.0.post6+133c1fe\">42001513<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag019\">10.1093\/jimmun\/vkag019<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Apr 15;215(4):vkag019. doi: 10.1093\/jimmun\/vkag019. ABSTRACT T cell immunity depends on the precise coordination of signaling networks with actin cytoskeleton remodeling, yet the molecular regulators of these processes remain incompletely defined. Flightless-1 (FLII) is a gelsolin-family actin regulator with unique leucine-rich repeats that can couple cytoskeletal dynamics to diverse signaling pathways. Here, using &#8230; <a title=\"Loss of the actin remodeling protein Flightless-1 impairs CD8 and regulatory T cell function\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/loss-of-the-actin-remodeling-protein-flightless-1-impairs-cd8-and-regulatory-t-cell-function\/\" aria-label=\"Read more about Loss of the actin remodeling protein Flightless-1 impairs CD8 and regulatory T cell function\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-62125","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/62125","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=62125"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/62125\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=62125"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=62125"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=62125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}