{"id":62277,"date":"2026-04-22T06:56:20","date_gmt":"2026-04-22T04:56:20","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/04\/22\/cannabidiol-prevents-mucosal-hiv-1-transmission-by-targeting-langerhans-cells-dendritic-cells-macrophages-and-t-cells-caio-cesar-barbosa-bomfim\/"},"modified":"2026-04-22T06:56:20","modified_gmt":"2026-04-22T04:56:20","slug":"cannabidiol-prevents-mucosal-hiv-1-transmission-by-targeting-langerhans-cells-dendritic-cells-macrophages-and-t-cells-caio-cesar-barbosa-bomfim","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/04\/22\/cannabidiol-prevents-mucosal-hiv-1-transmission-by-targeting-langerhans-cells-dendritic-cells-macrophages-and-t-cells-caio-cesar-barbosa-bomfim\/","title":{"rendered":"Cannabidiol prevents mucosal HIV-1 transmission by targeting Langerhans cells, dendritic cells, macrophages and T-cells. Caio C\u00e9sar Barbosa Bomfim"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 Apr 7:S1933-0219(26)00030-9. doi: 10.1016\/j.mucimm.2026.03.006. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>HIV-1 transmission depends on the structure and immune cell composition of mucosal epithelia. Transmission mechanisms involve direct infection of CD4<sup>+<\/sup> T-cells or macrophages, and indirect viral transfer to CD4<sup>+<\/sup> T-cells from Langerhans cells (LCs) or dendritic cells (DCs). LCs-mediated HIV-1 transfer is inhibited by the neuropeptide calcitonin gene-related peptide (CGRP), due to upstream activation in LCs of the transient receptor potential vanilloid 1 (TRPV1) ion channel. Herein, we investigated the potential anti-HIV-1roles of cannabidiol (CBD), the non-psychoactive compound in marijuana, which has well-described immunosuppressive functions and principally activates TRPV1 over its cognate CB1 and CB2 receptors. We found that via TRPV1 activation, CBDinhibitsin-vitroinfection of mucosal HIV-1 cellular targets. Specifically, CBD inhibits macrophages HIV-1 direct infection, and CD4<sup>+<\/sup> T-cells HIV-1 direct infection or upon viral transfer from LCsand DCs. Moreover, inhibition of macrophages infection and LCs-mediated HIV-1 transfer involves secreted CGRP.Importantly, CBD also blocks early events of HIV-1 transmission ex-vivo in human inner foreskin tissues, namely formation of epidermal LC-T-cell conjugates and resulting CD4<sup>+<\/sup> T-cells infection. Altogether, CBD inhibits infection of all HIV-1 cellular targets, and commercial CBD products might be repositioned as novel HIV-1 pre-exposure prophylaxis, namely &#8216;CBD PrEP&#8217;.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42014233\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260422005620&amp;v=2.19.0.post6+133c1fe\">42014233<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.03.006\">10.1016\/j.mucimm.2026.03.006<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 Apr 7:S1933-0219(26)00030-9. doi: 10.1016\/j.mucimm.2026.03.006. Online ahead of print. ABSTRACT HIV-1 transmission depends on the structure and immune cell composition of mucosal epithelia. Transmission mechanisms involve direct infection of CD4+ T-cells or macrophages, and indirect viral transfer to CD4+ T-cells from Langerhans cells (LCs) or dendritic cells (DCs). LCs-mediated HIV-1 transfer is inhibited &#8230; <a title=\"Cannabidiol prevents mucosal HIV-1 transmission by targeting Langerhans cells, dendritic cells, macrophages and T-cells. Caio C\u00e9sar Barbosa Bomfim\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/22\/cannabidiol-prevents-mucosal-hiv-1-transmission-by-targeting-langerhans-cells-dendritic-cells-macrophages-and-t-cells-caio-cesar-barbosa-bomfim\/\" aria-label=\"Read more about Cannabidiol prevents mucosal HIV-1 transmission by targeting Langerhans cells, dendritic cells, macrophages and T-cells. Caio C\u00e9sar Barbosa Bomfim\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-62277","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/62277","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=62277"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/62277\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=62277"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=62277"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=62277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}