{"id":62532,"date":"2026-04-24T06:52:50","date_gmt":"2026-04-24T04:52:50","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/04\/24\/murine-mait-cells-phenotypic-markers-plasticity-and-parallels-to-humans-dominic-haas\/"},"modified":"2026-04-24T06:52:50","modified_gmt":"2026-04-24T04:52:50","slug":"murine-mait-cells-phenotypic-markers-plasticity-and-parallels-to-humans-dominic-haas","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/04\/24\/murine-mait-cells-phenotypic-markers-plasticity-and-parallels-to-humans-dominic-haas\/","title":{"rendered":"Murine MAIT cells: phenotypic markers, plasticity, and parallels to humans. Dominic Haas"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2026 Apr 22:S1471-4906(26)00092-X. doi: 10.1016\/j.it.2026.04.001. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial metabolites. Recent studies have suggested numerous markers to define MAIT cells with distinct functional characteristics. This review synthesizes available data to identify markers that distinguish type 1 and type 3 murine MAIT cells. Inflammation can alter the expression of these markers, reflecting the plasticity of MAIT cells, which is discussed further. Comparative analysis with human MAIT cells reveals that type 1 and type 3 subsets are not as apparent. Although these have been described as activation states, unique human MAIT cell subsets exist across various tissues. By establishing a consensus for how to categorize MAIT cells, this review facilitates future research on these important lymphocytes.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42025540\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20260424005250&amp;v=2.19.0.post6+133c1fe\">42025540<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2026.04.001\">10.1016\/j.it.2026.04.001<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2026 Apr 22:S1471-4906(26)00092-X. doi: 10.1016\/j.it.2026.04.001. Online ahead of print. ABSTRACT Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial metabolites. Recent studies have suggested numerous markers to define MAIT cells with distinct functional characteristics. This review synthesizes available data to identify markers that distinguish type 1 and type 3 murine &#8230; <a title=\"Murine MAIT cells: phenotypic markers, plasticity, and parallels to humans. Dominic Haas\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/24\/murine-mait-cells-phenotypic-markers-plasticity-and-parallels-to-humans-dominic-haas\/\" aria-label=\"Read more about Murine MAIT cells: phenotypic markers, plasticity, and parallels to humans. Dominic Haas\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-62532","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/62532","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=62532"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/62532\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=62532"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=62532"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=62532"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}