{"id":62645,"date":"2026-04-25T07:15:30","date_gmt":"2026-04-25T05:15:30","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/04\/25\/proteasome-haem-bach2-axis-fuels-t-cell-exhaustion-jiajia-wang\/"},"modified":"2026-04-25T07:15:30","modified_gmt":"2026-04-25T05:15:30","slug":"proteasome-haem-bach2-axis-fuels-t-cell-exhaustion-jiajia-wang","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/04\/25\/proteasome-haem-bach2-axis-fuels-t-cell-exhaustion-jiajia-wang\/","title":{"rendered":"Proteasome-haem-BACH2 axis fuels T cell exhaustion. Jiajia Wang"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2026 Apr 23:S1471-4906(26)00095-5. doi: 10.1016\/j.it.2026.04.002. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>It remains unclear how mitochondrial stress instructs the transcriptional programme of terminal T cell exhaustion. In a recent study, Xu et al. uncovered a proteasome-haem-BACH2 axis in which haem liberated from damaged mitochondrial haemoproteins acts as a molecular messenger that couples mitochondrial injury to terminal T cell exhaustion.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42031636\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20260425011530&amp;v=2.19.0.post6+133c1fe\">42031636<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2026.04.002\">10.1016\/j.it.2026.04.002<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2026 Apr 23:S1471-4906(26)00095-5. doi: 10.1016\/j.it.2026.04.002. Online ahead of print. ABSTRACT It remains unclear how mitochondrial stress instructs the transcriptional programme of terminal T cell exhaustion. In a recent study, Xu et al. uncovered a proteasome-haem-BACH2 axis in which haem liberated from damaged mitochondrial haemoproteins acts as a molecular messenger that couples mitochondrial injury &#8230; <a title=\"Proteasome-haem-BACH2 axis fuels T cell exhaustion. Jiajia Wang\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/25\/proteasome-haem-bach2-axis-fuels-t-cell-exhaustion-jiajia-wang\/\" aria-label=\"Read more about Proteasome-haem-BACH2 axis fuels T cell exhaustion. Jiajia Wang\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-62645","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/62645","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=62645"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/62645\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=62645"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=62645"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=62645"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}