{"id":62858,"date":"2026-04-29T06:36:25","date_gmt":"2026-04-29T04:36:25","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/04\/29\/microbes-molecules-and-the-maternal-fetal-interface-rethinking-the-gut-placenta-axis-gabriela-barrientos\/"},"modified":"2026-04-29T06:36:25","modified_gmt":"2026-04-29T04:36:25","slug":"microbes-molecules-and-the-maternal-fetal-interface-rethinking-the-gut-placenta-axis-gabriela-barrientos","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/04\/29\/microbes-molecules-and-the-maternal-fetal-interface-rethinking-the-gut-placenta-axis-gabriela-barrientos\/","title":{"rendered":"Microbes, molecules, and the maternal-fetal interface: rethinking the gut-placenta axis. Gabriela Barrientos"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2026 Apr 27:S1471-4906(26)00071-2. doi: 10.1016\/j.it.2026.03.010. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Placental biology is increasingly framed through a signaling paradigm in which maternal microbiome-derived mediators-rather than microbial colonization-affect the function of the interface. This review synthesizes evidence that circulating microbial signals, including short-chain fatty acids, tryptophan-derived indoles, bile-acid-linked ligands, microbe-associated molecular patterns, and bacterial extracellular vesicles, are associated with placental vascular development, immune regulation, nutrient transport, and endocrine programs-processes central to pregnancy outcomes. We integrate mechanistic insights from gnotobiotic and supplementation models with limitations of human evidence and identify key translational gaps. The current evidence supports a model in which maternal microbial ecology shapes a network of circulating mediators that converge on interlinked placental pathways essential for placental function and fetal development.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42049610\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20260429003624&amp;v=2.19.0.post6+133c1fe\">42049610<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2026.03.010\">10.1016\/j.it.2026.03.010<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2026 Apr 27:S1471-4906(26)00071-2. doi: 10.1016\/j.it.2026.03.010. Online ahead of print. ABSTRACT Placental biology is increasingly framed through a signaling paradigm in which maternal microbiome-derived mediators-rather than microbial colonization-affect the function of the interface. This review synthesizes evidence that circulating microbial signals, including short-chain fatty acids, tryptophan-derived indoles, bile-acid-linked ligands, microbe-associated molecular patterns, and bacterial &#8230; <a title=\"Microbes, molecules, and the maternal-fetal interface: rethinking the gut-placenta axis. Gabriela Barrientos\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/29\/microbes-molecules-and-the-maternal-fetal-interface-rethinking-the-gut-placenta-axis-gabriela-barrientos\/\" aria-label=\"Read more about Microbes, molecules, and the maternal-fetal interface: rethinking the gut-placenta axis. Gabriela Barrientos\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-62858","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/62858","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=62858"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/62858\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=62858"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=62858"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=62858"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}