{"id":63179,"date":"2026-05-03T12:22:11","date_gmt":"2026-05-03T10:22:11","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/05\/03\/cooling-inflammation-through-metabolism-with-4-octyl-itaconate-hanna-f-vos-willenbockel\/"},"modified":"2026-05-03T12:22:11","modified_gmt":"2026-05-03T10:22:11","slug":"cooling-inflammation-through-metabolism-with-4-octyl-itaconate-hanna-f-vos-willenbockel","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/05\/03\/cooling-inflammation-through-metabolism-with-4-octyl-itaconate-hanna-f-vos-willenbockel\/","title":{"rendered":"Cooling inflammation through metabolism with 4-octyl itaconate. Hanna F Vo\u00df-Willenbockel"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2026 May 1:S1471-4906(26)00097-9. doi: 10.1016\/j.it.2026.04.004. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Itaconate is an immunomodulatory metabolite that links metabolism and inflammation. Li et al. uncover a mechanism by which itaconate and 4-octyl itaconate suppress cytokine signaling through the alkylation of tyrosine kinase 2 and Janus kinase 1. This study reveals a direct metabolic control of inflammation and highlights its therapeutic potential in sepsis.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42069477\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20260503062210&amp;v=2.19.0.post6+133c1fe\">42069477<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2026.04.004\">10.1016\/j.it.2026.04.004<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2026 May 1:S1471-4906(26)00097-9. doi: 10.1016\/j.it.2026.04.004. Online ahead of print. ABSTRACT Itaconate is an immunomodulatory metabolite that links metabolism and inflammation. Li et al. uncover a mechanism by which itaconate and 4-octyl itaconate suppress cytokine signaling through the alkylation of tyrosine kinase 2 and Janus kinase 1. This study reveals a direct metabolic control &#8230; <a title=\"Cooling inflammation through metabolism with 4-octyl itaconate. Hanna F Vo\u00df-Willenbockel\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/03\/cooling-inflammation-through-metabolism-with-4-octyl-itaconate-hanna-f-vos-willenbockel\/\" aria-label=\"Read more about Cooling inflammation through metabolism with 4-octyl itaconate. Hanna F Vo\u00df-Willenbockel\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-63179","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/63179","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=63179"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/63179\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=63179"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=63179"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=63179"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}