{"id":63183,"date":"2026-05-04T06:37:14","date_gmt":"2026-05-04T04:37:14","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/05\/04\/cytokine-networks-driving-eosinophil-functional-heterogeneity-james-i-king\/"},"modified":"2026-05-04T06:37:14","modified_gmt":"2026-05-04T04:37:14","slug":"cytokine-networks-driving-eosinophil-functional-heterogeneity-james-i-king","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/05\/04\/cytokine-networks-driving-eosinophil-functional-heterogeneity-james-i-king\/","title":{"rendered":"Cytokine networks driving eosinophil functional heterogeneity. James I King"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 May 1:100347. doi: 10.1016\/j.mucimm.2026.100347. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Eosinophils have traditionally been viewed as terminally differentiated type 2 effector cells involved in anti-helminth immunity and allergic inflammation. Recent advances in single-cell transcriptomics have refined this view, revealing substantial developmental and functional heterogeneity across tissues and inflammatory settings. Eosinophil development in the bone marrow is controlled by lineage-defining transcription factors and by cytokines such as IL-5, IL-3, GM-CSF and IL-33, which regulate progenitor expansion, maturation, mobilization and survival. After entering tissues, eosinophils integrate local cytokine, stromal, epithelial, microbial and metabolic signals to acquire context-dependent activation states. In this review, we summarize core developmental programs of eosinophils and examine how cytokine networks shape their responses across type 1, type 2 and type 17 immunity. We discuss evidence that eosinophils contribute not only to classical type 2 responses, but also to antimicrobial, cytotoxic, immunoregulatory and tissue-remodeling programs in non-type 2 settings, positioning them as highly plastic effectors with broad roles in host defense, tissue homeostasis and disease.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42070631\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260504003712&amp;v=2.19.0.post6+133c1fe\">42070631<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.100347\">10.1016\/j.mucimm.2026.100347<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 May 1:100347. doi: 10.1016\/j.mucimm.2026.100347. Online ahead of print. ABSTRACT Eosinophils have traditionally been viewed as terminally differentiated type 2 effector cells involved in anti-helminth immunity and allergic inflammation. Recent advances in single-cell transcriptomics have refined this view, revealing substantial developmental and functional heterogeneity across tissues and inflammatory settings. Eosinophil development in the &#8230; <a title=\"Cytokine networks driving eosinophil functional heterogeneity. James I King\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/04\/cytokine-networks-driving-eosinophil-functional-heterogeneity-james-i-king\/\" aria-label=\"Read more about Cytokine networks driving eosinophil functional heterogeneity. James I King\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-63183","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/63183","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=63183"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/63183\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=63183"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=63183"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=63183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}