{"id":64659,"date":"2026-05-15T06:29:38","date_gmt":"2026-05-15T04:29:38","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/05\/15\/factor-h-related-protein-1-deficiency-and-risk-of-severe-falciparum-malaria-in-ghanaian-children-a-cohort-analysisalliyah-uhmon-byrd-on-14-de-may-de-2026-at-1000\/"},"modified":"2026-05-15T06:29:38","modified_gmt":"2026-05-15T04:29:38","slug":"factor-h-related-protein-1-deficiency-and-risk-of-severe-falciparum-malaria-in-ghanaian-children-a-cohort-analysisalliyah-uhmon-byrd-on-14-de-may-de-2026-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/05\/15\/factor-h-related-protein-1-deficiency-and-risk-of-severe-falciparum-malaria-in-ghanaian-children-a-cohort-analysisalliyah-uhmon-byrd-on-14-de-may-de-2026-at-1000\/","title":{"rendered":"Factor H-Related Protein 1 Deficiency and Risk of Severe Falciparum Malaria in Ghanaian Children: A Cohort Analysis\u200bAlliyah Uhmon Byrd   on 14 de May de 2026 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2026 May 14:qiag063. doi: 10.1093\/jleuko\/qiag063. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Malaria caused by Plasmodium falciparum remains a leading cause of childhood mortality in sub-Saharan Africa. The intraerythrocytic parasite can evade complement-mediated destruction through recruitment of human Factor H (FH). In vitro, Factor H-Related Protein 1 (FHR-1) competes with FH for binding sites, suggesting a potential role in modulating complement activation during infection. Because one-third of Africans carry a CFHR3\/1 deletion, we examined the impact of FHR-1 deficiency on malaria severity. We analyzed plasma from 500 Ghanaian children presenting with different clinical manifestations. One-third of plasma samples lacked detectable FHR-1 protein, but logistic regression analysis revealed no association between FHR-1 deficiency and risk of severe malaria. In contrast, FHR-1 deficiency was overrepresented among children presenting with anemia and multiple syndromes and affected children exhibited markedly lower hemoglobin levels. These findings indicate that FHR-1 deficiency does not affect overall progression of severe falciparum malaria, but correlates with severe malaria anemia.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42135031\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20260515002938&amp;v=2.20.0\">42135031<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiag063\">10.1093\/jleuko\/qiag063<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2026 May 14:qiag063. doi: 10.1093\/jleuko\/qiag063. Online ahead of print. ABSTRACT Malaria caused by Plasmodium falciparum remains a leading cause of childhood mortality in sub-Saharan Africa. The intraerythrocytic parasite can evade complement-mediated destruction through recruitment of human Factor H (FH). In vitro, Factor H-Related Protein 1 (FHR-1) competes with FH for binding sites, &#8230; <a title=\"Factor H-Related Protein 1 Deficiency and Risk of Severe Falciparum Malaria in Ghanaian Children: A Cohort Analysis\u200bAlliyah Uhmon Byrd   on 14 de May de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/15\/factor-h-related-protein-1-deficiency-and-risk-of-severe-falciparum-malaria-in-ghanaian-children-a-cohort-analysisalliyah-uhmon-byrd-on-14-de-may-de-2026-at-1000\/\" aria-label=\"Read more about Factor H-Related Protein 1 Deficiency and Risk of Severe Falciparum Malaria in Ghanaian Children: A Cohort Analysis\u200bAlliyah Uhmon Byrd   on 14 de May de 2026 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-64659","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/64659","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=64659"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/64659\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=64659"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=64659"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=64659"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}