{"id":64701,"date":"2026-05-15T12:37:53","date_gmt":"2026-05-15T10:37:53","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/05\/15\/ets1-represses-blimp1-to-promote-germinal-center-t-follicular-helper-cell-differentiation-during-viral-infection\/"},"modified":"2026-05-15T12:37:53","modified_gmt":"2026-05-15T10:37:53","slug":"ets1-represses-blimp1-to-promote-germinal-center-t-follicular-helper-cell-differentiation-during-viral-infection","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/05\/15\/ets1-represses-blimp1-to-promote-germinal-center-t-follicular-helper-cell-differentiation-during-viral-infection\/","title":{"rendered":"Ets1 represses Blimp1 to promote germinal center T follicular helper cell differentiation during viral infection"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 May 14;215(5):vkag096. doi: 10.1093\/jimmun\/vkag096.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Following acute viral infection, na\u00efve CD4+ T cells differentiate into T helper 1 (Th1) and T follicular helper (Tfh) cells. The transcription factor Ets1 represses Tfh cell formation and function following protein immunization; however, whether Ets1 regulates Tfh differentiation in viral infection is unclear. Here, we demonstrate that during acute viral infection, conditional deletion of Ets1 in CD4+ T cells impairs germinal center (GC) Tfh differentiation and function, resulting in diminished GC B-cell responses, reduced IgG2c class switching, and impaired antibody production. Mechanistically, Ets1 deficiency results in aberrant upregulation of Blimp1 to negatively impact early Tfh and GC Tfh cell differentiation in a cell-intrinsic manner. Early Tfh differentiation is partially restored by knockdown of Blimp1 in Ets1-deficient T cells. In contrast, during protein immunization where Blimp1 is not highly expressed, Ets1 is not required to repress expression of CD25 and Blimp1 in early Tfh cells, and Ets1 deficiency results in a cell-intrinsic enhancement in GC Tfh differentiation. Collectively, these results demonstrate that Ets1 is a positive regulator of GC Tfh cell differentiation and function during viral infection, highlighting a context-dependent role for Ets1 in GC Tfh cell responses.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42136567\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260515063752&amp;v=2.20.0\">42136567<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag096\">10.1093\/jimmun\/vkag096<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 May 14;215(5):vkag096. doi: 10.1093\/jimmun\/vkag096. ABSTRACT Following acute viral infection, na\u00efve CD4+ T cells differentiate into T helper 1 (Th1) and T follicular helper (Tfh) cells. The transcription factor Ets1 represses Tfh cell formation and function following protein immunization; however, whether Ets1 regulates Tfh differentiation in viral infection is unclear. Here, we demonstrate &#8230; <a title=\"Ets1 represses Blimp1 to promote germinal center T follicular helper cell differentiation during viral infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/15\/ets1-represses-blimp1-to-promote-germinal-center-t-follicular-helper-cell-differentiation-during-viral-infection\/\" aria-label=\"Read more about Ets1 represses Blimp1 to promote germinal center T follicular helper cell differentiation during viral infection\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-64701","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/64701","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=64701"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/64701\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=64701"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=64701"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=64701"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}