{"id":64744,"date":"2026-05-17T12:30:25","date_gmt":"2026-05-17T10:30:25","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/05\/17\/rethinking-the-origins-and-functions-of-adaptive-immunity-derick-okwan-duodu\/"},"modified":"2026-05-17T12:30:25","modified_gmt":"2026-05-17T10:30:25","slug":"rethinking-the-origins-and-functions-of-adaptive-immunity-derick-okwan-duodu","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/05\/17\/rethinking-the-origins-and-functions-of-adaptive-immunity-derick-okwan-duodu\/","title":{"rendered":"Rethinking the origins and functions of adaptive immunity. Derick Okwan-Duodu"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2026 May 16:S1471-4906(26)00101-8. doi: 10.1016\/j.it.2026.04.008. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The adaptive immune system (AIS) is traditionally viewed as a defensive vertebrate innovation forged by pathogen pressure. Yet many of its core features suggest it is a homeostatic, regulatory circuit, not simply a sophisticated means of antimicrobial warfare. The horizontal transfer of mitochondria&#8211;endogenous endosymbiotic organelles-is a conserved mechanism for maintaining tissue homeostasis through metabolic rescue but can alter a cell&#8217;s identity and provoke immune responses. We propose that escalating multicellular complexity accommodated mitochondrial mobility-and the inevitable intrinsic immunological danger it presents-through a complementary supervisory system with buffering (tolerance), contextualization (specificity), memory, and eliminatory capacities. This perspective reframes the AIS as a constitutive danger management network, integrating tissue homeostasis, metabolic surveillance, immune tolerance, and immunological defense.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42142972\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20260517063024&amp;v=2.20.0\">42142972<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2026.04.008\">10.1016\/j.it.2026.04.008<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2026 May 16:S1471-4906(26)00101-8. doi: 10.1016\/j.it.2026.04.008. Online ahead of print. ABSTRACT The adaptive immune system (AIS) is traditionally viewed as a defensive vertebrate innovation forged by pathogen pressure. Yet many of its core features suggest it is a homeostatic, regulatory circuit, not simply a sophisticated means of antimicrobial warfare. The horizontal transfer of mitochondria&#8211;endogenous &#8230; <a title=\"Rethinking the origins and functions of adaptive immunity. Derick Okwan-Duodu\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/17\/rethinking-the-origins-and-functions-of-adaptive-immunity-derick-okwan-duodu\/\" aria-label=\"Read more about Rethinking the origins and functions of adaptive immunity. Derick Okwan-Duodu\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-64744","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/64744","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=64744"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/64744\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=64744"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=64744"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=64744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}