{"id":65264,"date":"2026-05-22T18:54:00","date_gmt":"2026-05-22T16:54:00","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/05\/22\/the-emerging-roles-of-nfil3-in-immunity\/"},"modified":"2026-05-22T18:54:00","modified_gmt":"2026-05-22T16:54:00","slug":"the-emerging-roles-of-nfil3-in-immunity","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/05\/22\/the-emerging-roles-of-nfil3-in-immunity\/","title":{"rendered":"The emerging roles of NFIL3 in immunity"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 May 14;215(5):vkag103. doi: 10.1093\/jimmun\/vkag103.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>NFIL3 (E4BP4) is a basic leucine zipper transcription factor best known for its roles in circadian regulation. It functions primarily as a transcriptional repressor through competitive DNA binding and the recruitment of histone-modifying complexes. More recently, NFIL3 has emerged as a critical regulator of immunity. It is essential for the development of multiple immune cell subsets, including NK cells and CD8+ dendritic cells, and modulates the activity of many others. For instance, NFIL3 influences B cell class switching and cytokine production in T helper subsets and macrophages. Its expression is dynamically controlled by cytokines and environmental signals, positioning NFIL3 as a key integrator of circadian and immune pathways. Consistent with these roles, recent studies have implicated NFIL3 in multiple immune-mediated diseases, including colitis, lupus, and arthritis. In this review, we highlight NFIL3&#8217;s immunological functions, its evolutionary conservation, and its emerging role as a context-dependent modulator of inflammation and immune homeostasis.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42171337\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260522125400&amp;v=2.20.0\">42171337<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag103\">10.1093\/jimmun\/vkag103<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 May 14;215(5):vkag103. doi: 10.1093\/jimmun\/vkag103. ABSTRACT NFIL3 (E4BP4) is a basic leucine zipper transcription factor best known for its roles in circadian regulation. It functions primarily as a transcriptional repressor through competitive DNA binding and the recruitment of histone-modifying complexes. More recently, NFIL3 has emerged as a critical regulator of immunity. It is &#8230; <a title=\"The emerging roles of NFIL3 in immunity\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/22\/the-emerging-roles-of-nfil3-in-immunity\/\" aria-label=\"Read more about The emerging roles of NFIL3 in immunity\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-65264","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/65264","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=65264"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/65264\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=65264"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=65264"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=65264"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}