{"id":65312,"date":"2026-05-23T12:15:34","date_gmt":"2026-05-23T10:15:34","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/05\/23\/the-multifaceted-role-of-b-lymphocytes-in-type-1-diabetes-salma-ayman-khalefa\/"},"modified":"2026-05-23T12:15:34","modified_gmt":"2026-05-23T10:15:34","slug":"the-multifaceted-role-of-b-lymphocytes-in-type-1-diabetes-salma-ayman-khalefa","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/05\/23\/the-multifaceted-role-of-b-lymphocytes-in-type-1-diabetes-salma-ayman-khalefa\/","title":{"rendered":"The multifaceted role of B lymphocytes in type 1 diabetes. Salma Ayman Khalefa"},"content":{"rendered":"<div>\n<p><b>Semin Immunol<\/b>. 2026 May 22;82:102034. doi: 10.1016\/j.smim.2026.102034. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Lymphocytes B cells (B cells) play a determinant role in the pathogenesis of type 1 diabetes (T1D); indeed, B cells antigen-presentation capabilities are largely described as a main contributing pathogenic factor. Recent evidences highlighted the role of islet antigen-reactive B cells as a perpetuated contributor to autoantibodies seroconversion and the progression to the late stages of the disease. A loss of B cells anergy towards islet-specific antigens, can be recognized in T1D. Aside from their well characterized role during the pathogenesis and early onset of T1D, a fundamental regulatory role of a subset of B cells, namely regulatory B cells, has proven its relevance in the time course of the disease. Since targeting B cells showed little or no additional benefits; instead, harnessing strategies to expand B regulatory cells could represent an attractive therapeutic path to tackle inflammation and curb diabetes.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42172886\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=9009458&amp;ff=20260523061533&amp;v=2.20.0\">42172886<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.smim.2026.102034\">10.1016\/j.smim.2026.102034<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Semin Immunol. 2026 May 22;82:102034. doi: 10.1016\/j.smim.2026.102034. Online ahead of print. ABSTRACT Lymphocytes B cells (B cells) play a determinant role in the pathogenesis of type 1 diabetes (T1D); indeed, B cells antigen-presentation capabilities are largely described as a main contributing pathogenic factor. Recent evidences highlighted the role of islet antigen-reactive B cells as a &#8230; <a title=\"The multifaceted role of B lymphocytes in type 1 diabetes. Salma Ayman Khalefa\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/23\/the-multifaceted-role-of-b-lymphocytes-in-type-1-diabetes-salma-ayman-khalefa\/\" aria-label=\"Read more about The multifaceted role of B lymphocytes in type 1 diabetes. Salma Ayman Khalefa\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,110],"tags":[],"class_list":["post-65312","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-seminars-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/65312","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=65312"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/65312\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=65312"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=65312"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=65312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}