{"id":65355,"date":"2026-05-25T07:15:32","date_gmt":"2026-05-25T05:15:32","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/05\/25\/systemic-ige-promotes-allergic-rhinitis-by-licensing-th2-to-tfh-conversion-and-local-ige-production-takuya-nakai\/"},"modified":"2026-05-25T07:15:32","modified_gmt":"2026-05-25T05:15:32","slug":"systemic-ige-promotes-allergic-rhinitis-by-licensing-th2-to-tfh-conversion-and-local-ige-production-takuya-nakai","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/05\/25\/systemic-ige-promotes-allergic-rhinitis-by-licensing-th2-to-tfh-conversion-and-local-ige-production-takuya-nakai\/","title":{"rendered":"Systemic IgE promotes allergic rhinitis by licensing Th2-to-Tfh conversion and local IgE production. Takuya Nakai"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 May 23:100351. doi: 10.1016\/j.mucimm.2026.100351. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Although systemic allergen-specific IgE is an essential biomarker for allergic rhinitis (AR), its mechanistic contribution to symptom development remains unclear. Here, using mouse models, we investigated how systemic antigen-specific IgE influences AR symptoms and local type 2 inflammation. Mice were adoptively sensitized with ovalbumin (OVA)-specific IgE (OVA-IgE) and\/or in vitro-differentiated OVA-specific Th2 (OVA-Th2) cells, followed by repeated intranasal OVA exposure. AR symptoms (sneezing) and the appearance of IgE-producing cells in the cervical lymph nodes (cLNs) and nasopharynx-associated lymphoid tissue were observed only in mice that received both OVA-Th2 cells and OVA-IgE. These responses were absent in recipients lacking factors required for IgE production, Rag2<sup>-\/-<\/sup>, Aid<sup>-\/-<\/sup>, and Stat6<sup>-\/-<\/sup> mice, or in mice receiving OVA-Th2 cells deficient in IL-4-producing T follicular helper (Tfh) cell differentiation. Notably, when IgE-independent mast cell activation was induced by repeated intranasal administration of compound 48\/80 in mice that had received OVA-Th2 cells, subsequent OVA challenge elicited OVA-specific AR symptoms and induced IgE-producing cells in the cLNs. Single-cell RNA sequencing revealed that systemic OVA-IgE facilitated the differentiation of OVA-Th2 cells into Tfh cells upon OVA challenge. Together, systemic IgE-mediated mast cell\/basophil activation promoted Th2-to-Tfh differentiation and local IgE production, thereby contributing to the AR symptoms.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42178092\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260525011531&amp;v=2.20.0\">42178092<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.100351\">10.1016\/j.mucimm.2026.100351<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 May 23:100351. doi: 10.1016\/j.mucimm.2026.100351. Online ahead of print. ABSTRACT Although systemic allergen-specific IgE is an essential biomarker for allergic rhinitis (AR), its mechanistic contribution to symptom development remains unclear. Here, using mouse models, we investigated how systemic antigen-specific IgE influences AR symptoms and local type 2 inflammation. Mice were adoptively sensitized with &#8230; <a title=\"Systemic IgE promotes allergic rhinitis by licensing Th2-to-Tfh conversion and local IgE production. Takuya Nakai\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/25\/systemic-ige-promotes-allergic-rhinitis-by-licensing-th2-to-tfh-conversion-and-local-ige-production-takuya-nakai\/\" aria-label=\"Read more about Systemic IgE promotes allergic rhinitis by licensing Th2-to-Tfh conversion and local IgE production. Takuya Nakai\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-65355","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/65355","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=65355"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/65355\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=65355"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=65355"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=65355"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}