{"id":66281,"date":"2026-06-05T06:52:03","date_gmt":"2026-06-05T04:52:03","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/06\/05\/tuft-cells-protect-against-intestinal-inflammation-through-histone-deacetylase-3-emily-m-eshleman\/"},"modified":"2026-06-05T06:52:03","modified_gmt":"2026-06-05T04:52:03","slug":"tuft-cells-protect-against-intestinal-inflammation-through-histone-deacetylase-3-emily-m-eshleman","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/06\/05\/tuft-cells-protect-against-intestinal-inflammation-through-histone-deacetylase-3-emily-m-eshleman\/","title":{"rendered":"Tuft cells protect against intestinal inflammation through histone deacetylase 3. Emily M Eshleman"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 Jun 3:100356. doi: 10.1016\/j.mucimm.2026.100356. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>While intestinal tuft cells are well known to promote type 2 immunity, their role in inflammatory bowel disease (IBD) remains unclear. Here, we show that tuft cells are reduced in the distal intestine of pediatric IBD patients and that tuft cell-deficient mice exhibited increased susceptibility to intestinal inflammation. Histone deacetylase 3 (HDAC3) expression in intestinal stem cells is essential for tuft cell differentiation. Interestingly, single-cell analyses revealed that HDAC3 was also enriched in mature tuft cells compared to other differentiated epithelial populations. Generation of tuft cell-specific HDAC3 knockout mice (HDAC3<sup>\u0394Tuft<\/sup>) showed that expression of canonical tuft cell pathways were impaired in HDAC3<sup>\u0394Tuft<\/sup> mice, suggesting that HDAC3 regulates tuft cell-intrinsic function. HDAC3<sup>\u0394Tuft<\/sup> mice did not exhibit a significant difference in tuft cell numbers, however loss of HDAC3 specifically in tuft cells promoted colitis. Transcriptional analyses of ileal and colonic epithelium demonstrated dampened repair responses in HDAC3<sup>\u0394Tuft<\/sup> mice relative to control mice. Furthermore, HDAC3 inhibition in human colonoids similarly downregulated tuft cell-associated cytokines and eicosanoid pathways that promote epithelial repair. Collectively, these data indicate that enhancing tuft cell function may prevent or treat IBD, and that tuft cell-intrinsic regulation by HDAC3 limits susceptibility to intestinal damage and inflammation.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42242519\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260605005202&amp;v=2.20.0\">42242519<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.100356\">10.1016\/j.mucimm.2026.100356<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 Jun 3:100356. doi: 10.1016\/j.mucimm.2026.100356. Online ahead of print. ABSTRACT While intestinal tuft cells are well known to promote type 2 immunity, their role in inflammatory bowel disease (IBD) remains unclear. Here, we show that tuft cells are reduced in the distal intestine of pediatric IBD patients and that tuft cell-deficient mice exhibited &#8230; <a title=\"Tuft cells protect against intestinal inflammation through histone deacetylase 3. Emily M Eshleman\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/05\/tuft-cells-protect-against-intestinal-inflammation-through-histone-deacetylase-3-emily-m-eshleman\/\" aria-label=\"Read more about Tuft cells protect against intestinal inflammation through histone deacetylase 3. Emily M Eshleman\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-66281","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/66281","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=66281"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/66281\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=66281"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=66281"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=66281"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}