{"id":66397,"date":"2026-06-06T07:26:30","date_gmt":"2026-06-06T05:26:30","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/06\/06\/sirt6-bridges-glycolysis-and-epigenetics-to-neutrophilic-asthma-zhan-wang\/"},"modified":"2026-06-06T07:26:30","modified_gmt":"2026-06-06T05:26:30","slug":"sirt6-bridges-glycolysis-and-epigenetics-to-neutrophilic-asthma-zhan-wang","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/06\/06\/sirt6-bridges-glycolysis-and-epigenetics-to-neutrophilic-asthma-zhan-wang\/","title":{"rendered":"SIRT6 bridges glycolysis and epigenetics to neutrophilic asthma. Zhan Wang"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2026 Jun 5:S1471-4906(26)00127-4. doi: 10.1016\/j.it.2026.05.002. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Neutrophil asthma is a severe, corticosteroid-resistant subtype characterized by airway neutrophilia and declining lung function. Su et al. identify a sirtuin 6-lactate dehydrogenase A-histone lactylation axis that links macrophage glycolysis to epigenetic chemokine regulation, offering mechanistic insight into neutrophil recruitment and highlighting potential therapeutic targets.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42248697\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20260606012629&amp;v=2.20.0\">42248697<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2026.05.002\">10.1016\/j.it.2026.05.002<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2026 Jun 5:S1471-4906(26)00127-4. doi: 10.1016\/j.it.2026.05.002. Online ahead of print. ABSTRACT Neutrophil asthma is a severe, corticosteroid-resistant subtype characterized by airway neutrophilia and declining lung function. Su et al. identify a sirtuin 6-lactate dehydrogenase A-histone lactylation axis that links macrophage glycolysis to epigenetic chemokine regulation, offering mechanistic insight into neutrophil recruitment and highlighting potential &#8230; <a title=\"SIRT6 bridges glycolysis and epigenetics to neutrophilic asthma. Zhan Wang\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/06\/sirt6-bridges-glycolysis-and-epigenetics-to-neutrophilic-asthma-zhan-wang\/\" aria-label=\"Read more about SIRT6 bridges glycolysis and epigenetics to neutrophilic asthma. Zhan Wang\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-66397","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/66397","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=66397"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/66397\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=66397"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=66397"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=66397"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}