{"id":66509,"date":"2026-06-09T01:49:31","date_gmt":"2026-06-08T23:49:31","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/06\/09\/sustained-antigen-specific-cd8-t-cell-immunity-post-mrna-booster-requires-notch-pathway-activation\/"},"modified":"2026-06-09T01:49:31","modified_gmt":"2026-06-08T23:49:31","slug":"sustained-antigen-specific-cd8-t-cell-immunity-post-mrna-booster-requires-notch-pathway-activation","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/06\/09\/sustained-antigen-specific-cd8-t-cell-immunity-post-mrna-booster-requires-notch-pathway-activation\/","title":{"rendered":"Sustained antigen-specific CD8+ T cell immunity post-mRNA booster requires notch pathway activation"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Jun 7;215(6):vkag074. doi: 10.1093\/jimmun\/vkag074.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Messenger RNA (mRNA) vaccines effectively induce protective immunity, but antigen-specific CD8+ T cell responses exhibit limited persistence. In this study, we aimed to assess CD8+ T cell responses following a third dose of the Pfizer BNT162b2 COVID-19 vaccine and identify factors contributing to their longevity. Using HLA tetramers, we analyzed antigen-specific CD8+ T cells in 141 vaccinated individuals (86.5% female) and identified 2 groups: those with strong responses (strong group) and those with weak responses (weak group) 6 mo after the third mRNA vaccination. Transcriptomic analysis revealed that Notch signaling was upregulated in the strong group, and in vitro, the inhibition of Notch signaling significantly reduced CD8+ T cell expansion. These findings suggest that Notch signaling may contribute to maintain long-term antigen-specific CD8+ T cell responses following mRNA vaccination. Targeting this pathway could offer novel strategies for enhancing vaccine-induced cellular immunity and long-lasting protection.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42258807\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260608194930&amp;v=2.20.0\">42258807<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag074\">10.1093\/jimmun\/vkag074<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Jun 7;215(6):vkag074. doi: 10.1093\/jimmun\/vkag074. ABSTRACT Messenger RNA (mRNA) vaccines effectively induce protective immunity, but antigen-specific CD8+ T cell responses exhibit limited persistence. In this study, we aimed to assess CD8+ T cell responses following a third dose of the Pfizer BNT162b2 COVID-19 vaccine and identify factors contributing to their longevity. Using HLA &#8230; <a title=\"Sustained antigen-specific CD8+ T cell immunity post-mRNA booster requires notch pathway activation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/09\/sustained-antigen-specific-cd8-t-cell-immunity-post-mrna-booster-requires-notch-pathway-activation\/\" aria-label=\"Read more about Sustained antigen-specific CD8+ T cell immunity post-mRNA booster requires notch pathway activation\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-66509","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/66509","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=66509"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/66509\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=66509"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=66509"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=66509"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}