{"id":67462,"date":"2026-06-13T12:55:46","date_gmt":"2026-06-13T10:55:46","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/06\/13\/rotavirus-specific-intestinal-resident-memory-t-cells-induced-by-oral-vaccination-in-early-life-mice-may-contribute-to-protective-immunitycatherine-montenegro-on-13-de-june-de-2026-at-1000\/"},"modified":"2026-06-13T12:55:46","modified_gmt":"2026-06-13T10:55:46","slug":"rotavirus-specific-intestinal-resident-memory-t-cells-induced-by-oral-vaccination-in-early-life-mice-may-contribute-to-protective-immunitycatherine-montenegro-on-13-de-june-de-2026-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/06\/13\/rotavirus-specific-intestinal-resident-memory-t-cells-induced-by-oral-vaccination-in-early-life-mice-may-contribute-to-protective-immunitycatherine-montenegro-on-13-de-june-de-2026-at-1000\/","title":{"rendered":"Rotavirus-specific intestinal resident memory T cells induced by oral vaccination in early-life mice may contribute to protective immunity\u200bCatherine Montenegro   on 13 de June de 2026 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2026 Jun 13:qiag080. doi: 10.1093\/jleuko\/qiag080. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Resident memory T cells (Trm) are key mediators of protective immunity at barrier sites, yet their development during early life remains poorly defined. Here, we show that early-life oral vaccination with a heterologous rhesus rotavirus (RV) induces short-lived intestinal Trm that are negative by intravascular staining and express a CD44+CD69+CD103+\/-P2X7R+ phenotype. Blocking lymphocyte homing with an anti-\u03b14\u03b27 antibody during vaccination did not alter the magnitude of RV-specific intestinal T cells or affect protection following murine RV challenge. In contrast, reduction of RV-specific intraepithelial lymphocytes by nicotinamide adenine dinucleotide treatment, or genetic deletion of the aryl hydrocarbon receptor repressor (Ahrr-\/- mice)-which also exhibit decreased intraepithelial CD8+ T cells after infection-resulted in increased viral antigen shedding upon challenge. These results suggest that intestinal Trm cells induced by early-life vaccination may contribute to protection against RV infection.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42287029\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20260613065544&amp;v=2.20.0\">42287029<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiag080\">10.1093\/jleuko\/qiag080<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2026 Jun 13:qiag080. doi: 10.1093\/jleuko\/qiag080. Online ahead of print. ABSTRACT Resident memory T cells (Trm) are key mediators of protective immunity at barrier sites, yet their development during early life remains poorly defined. Here, we show that early-life oral vaccination with a heterologous rhesus rotavirus (RV) induces short-lived intestinal Trm that are &#8230; <a title=\"Rotavirus-specific intestinal resident memory T cells induced by oral vaccination in early-life mice may contribute to protective immunity\u200bCatherine Montenegro   on 13 de June de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/13\/rotavirus-specific-intestinal-resident-memory-t-cells-induced-by-oral-vaccination-in-early-life-mice-may-contribute-to-protective-immunitycatherine-montenegro-on-13-de-june-de-2026-at-1000\/\" aria-label=\"Read more about Rotavirus-specific intestinal resident memory T cells induced by oral vaccination in early-life mice may contribute to protective immunity\u200bCatherine Montenegro   on 13 de June de 2026 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-67462","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/67462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=67462"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/67462\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=67462"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=67462"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=67462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}