{"id":67573,"date":"2026-06-16T07:23:10","date_gmt":"2026-06-16T05:23:10","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/06\/16\/context-dependent-androgen-control-of-t-cell-immunity-jianhua-xiong\/"},"modified":"2026-06-16T07:23:10","modified_gmt":"2026-06-16T05:23:10","slug":"context-dependent-androgen-control-of-t-cell-immunity-jianhua-xiong","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/06\/16\/context-dependent-androgen-control-of-t-cell-immunity-jianhua-xiong\/","title":{"rendered":"Context-dependent androgen control of T cell immunity. Jianhua Xiong"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2026 Jun 15:S1471-4906(26)00156-0. doi: 10.1016\/j.it.2026.06.004. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>While androgen deprivation is widely used in urological oncology to restrain tumor growth and prevent T cell exhaustion, Lee et al. reveal a striking reversal in glioblastoma. In glioblastoma, androgen loss triggers microglial cytokines, activates the hypothalamic-pituitary-adrenal axis, and induces glucocorticoid-dependent T cell suppression, which accelerates tumor progression.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42297713\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20260616012309&amp;v=2.20.0\">42297713<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2026.06.004\">10.1016\/j.it.2026.06.004<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2026 Jun 15:S1471-4906(26)00156-0. doi: 10.1016\/j.it.2026.06.004. Online ahead of print. ABSTRACT While androgen deprivation is widely used in urological oncology to restrain tumor growth and prevent T cell exhaustion, Lee et al. reveal a striking reversal in glioblastoma. In glioblastoma, androgen loss triggers microglial cytokines, activates the hypothalamic-pituitary-adrenal axis, and induces glucocorticoid-dependent T cell &#8230; <a title=\"Context-dependent androgen control of T cell immunity. Jianhua Xiong\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/16\/context-dependent-androgen-control-of-t-cell-immunity-jianhua-xiong\/\" aria-label=\"Read more about Context-dependent androgen control of T cell immunity. Jianhua Xiong\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-67573","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/67573","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=67573"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/67573\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=67573"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=67573"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=67573"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}