{"id":67820,"date":"2026-06-18T12:00:00","date_gmt":"2026-06-18T10:00:00","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/06\/18\/humoral-immune-abnormalities-in-transient-childhood-neutropenia-insights-from-a-10-year-cohort-study-in-a-tertiary-center\/"},"modified":"2026-06-18T12:00:00","modified_gmt":"2026-06-18T10:00:00","slug":"humoral-immune-abnormalities-in-transient-childhood-neutropenia-insights-from-a-10-year-cohort-study-in-a-tertiary-center","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/06\/18\/humoral-immune-abnormalities-in-transient-childhood-neutropenia-insights-from-a-10-year-cohort-study-in-a-tertiary-center\/","title":{"rendered":"Humoral Immune Abnormalities in Transient Childhood Neutropenia: Insights From a 10-year Cohort Study in a Tertiary Center"},"content":{"rendered":"<div>\n<p><b>J Clin Immunol<\/b>. 2026 Jun 18. doi: 10.1007\/s10875-026-02042-w. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>PURPOSE: Transient neutropenia in early childhood is a relatively common condition often associated with neutrophil-specific autoantibodies; however, its connection to broader humoral immune system abnormalities remains poorly understood.<\/p>\n<p>METHODS: The current study investigated this relationship through a retrospective cohort analysis at a pediatric tertiary center in Switzerland.<\/p>\n<p>RESULTS: In total, 92 children aged 0 to 6 years seen at our hospital between January 2014 and December 2023 were included in the final cohort. Of the 68 children who underwent detailed immunological testing, 52 (77%) exhibited humoral abnormalities, with 24 (35%) classified as moderate and 28 (41%) as mild. Patients with humoral abnormalities exhibited neutrophil-specific autoantibodies less commonly (56% vs. 100%, p = 0.003), had higher minimum absolute neutrophil counts (ANC) (median minimum ANC 0.26 vs. 0.05 \u00d7 10<sup>9<\/sup>\/L, p = 0.002), and a shorter duration of neutropenia (median duration 12.1 vs. 28.5 months, p = 0.001) compared to patients without abnormalities. Additionally, 36% of patients with humoral abnormalities had inadequate vaccine antibodies, compared to none in the group without abnormalities. These findings suggest that patients with humoral abnormalities may have a higher risk of infection and could benefit from additional counseling and timely booster vaccinations.<\/p>\n<p>CONCLUSION: This study highlights a potential causal relationship between humoral immune system abnormalities and transient neutropenia in early childhood. Routine immunological assessments in children with early-onset (autoimmune) neutropenia are likely to aid in patient management and family counseling.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42315772\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_campaign=journals&amp;utm_content=8102137&amp;ff=20260619005901&amp;v=2.20.0\">42315772<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1007\/s10875-026-02042-w\">10.1007\/s10875-026-02042-w<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Clin Immunol. 2026 Jun 18. doi: 10.1007\/s10875-026-02042-w. Online ahead of print. ABSTRACT PURPOSE: Transient neutropenia in early childhood is a relatively common condition often associated with neutrophil-specific autoantibodies; however, its connection to broader humoral immune system abnormalities remains poorly understood. METHODS: The current study investigated this relationship through a retrospective cohort analysis at a &#8230; <a title=\"Humoral Immune Abnormalities in Transient Childhood Neutropenia: Insights From a 10-year Cohort Study in a Tertiary Center\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/18\/humoral-immune-abnormalities-in-transient-childhood-neutropenia-insights-from-a-10-year-cohort-study-in-a-tertiary-center\/\" aria-label=\"Read more about Humoral Immune Abnormalities in Transient Childhood Neutropenia: Insights From a 10-year Cohort Study in a Tertiary Center\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,42],"tags":[],"class_list":["post-67820","post","type-post","status-publish","format-standard","hentry","category-journal-of-clinical-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/67820","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=67820"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/67820\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=67820"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=67820"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=67820"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}