{"id":67940,"date":"2026-06-22T05:26:46","date_gmt":"2026-06-22T03:26:46","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/06\/22\/bptf-is-essential-for-vaccine-induced-germinal-center-b-cell-responses\/"},"modified":"2026-06-22T05:26:46","modified_gmt":"2026-06-22T03:26:46","slug":"bptf-is-essential-for-vaccine-induced-germinal-center-b-cell-responses","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/06\/22\/bptf-is-essential-for-vaccine-induced-germinal-center-b-cell-responses\/","title":{"rendered":"BPTF is essential for vaccine-induced germinal center B cell responses"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Jun 7;215(6):vkag126. doi: 10.1093\/jimmun\/vkag126.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Germinal centers (GCs) are microanatomical structures in which antigen-specific B cells undergo proliferation, somatic hypermutation, and affinity-based competition to select high-affinity clones that differentiate into memory B cells and plasma cells (PCs). B cell progression through the GC is tightly regulated, and the molecular determinants that modulate GC B cell proliferation and survival are still under investigation. Here, we use a conditional deletion mouse model to demonstrate that bromodomain PHD finger transcription factor (BPTF), a subunit of the nucleosome remodeling factor chromatin remodeling complex, is required for robust GC B cell responses following vaccination. In GC B cells, Bptf loss induces a stress-like transcriptional profile and a shift toward PC identity-defining transcriptional programing, although this does not lead to accumulation of functional PCs. Rather, we show that BPTF-deficient GC B cells are prone to cell death. Cumulatively, our data demonstrate that BPTF is necessary for GC B cell maintenance and robust antigen-specific B cell responses.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42322234\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260621232644&amp;v=2.20.0\">42322234<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag126\">10.1093\/jimmun\/vkag126<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Jun 7;215(6):vkag126. doi: 10.1093\/jimmun\/vkag126. ABSTRACT Germinal centers (GCs) are microanatomical structures in which antigen-specific B cells undergo proliferation, somatic hypermutation, and affinity-based competition to select high-affinity clones that differentiate into memory B cells and plasma cells (PCs). B cell progression through the GC is tightly regulated, and the molecular determinants that modulate &#8230; <a title=\"BPTF is essential for vaccine-induced germinal center B cell responses\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/22\/bptf-is-essential-for-vaccine-induced-germinal-center-b-cell-responses\/\" aria-label=\"Read more about BPTF is essential for vaccine-induced germinal center B cell responses\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-67940","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/67940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=67940"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/67940\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=67940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=67940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=67940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}