{"id":68066,"date":"2026-06-23T03:51:46","date_gmt":"2026-06-23T01:51:46","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/06\/23\/adaptive-immune-responses-against-lachnospiraceae-derived-flagellins-and-their-role-in-inflammatory-bowel-disease-danielle-m-h-barendregt\/"},"modified":"2026-06-23T03:51:46","modified_gmt":"2026-06-23T01:51:46","slug":"adaptive-immune-responses-against-lachnospiraceae-derived-flagellins-and-their-role-in-inflammatory-bowel-disease-danielle-m-h-barendregt","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/06\/23\/adaptive-immune-responses-against-lachnospiraceae-derived-flagellins-and-their-role-in-inflammatory-bowel-disease-danielle-m-h-barendregt\/","title":{"rendered":"Adaptive immune responses against Lachnospiraceae-derived flagellins and their role in inflammatory bowel disease. Dani\u00eblle M H Barendregt"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 Jun 22:100365. doi: 10.1016\/j.mucimm.2026.100365. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Adaptive immune responses, including B and T cell responses, play important roles in establishing and maintaining the mutualistic relationship between the host and intestinal microbiota. Host-microbiota mutualism is disrupted in various immune-mediated inflammatory diseases, including Crohn&#8217;s disease (CD). Aberrant inflammatory memory CD4<sup>+<\/sup> T cell responses contribute to disease chronicity in CD. One of the few identified microbial targets of the CD-associated immune response that has been extensively studied is Lachnospiraceae-derived flagellin protein. In this review, we provide an overview of current knowledge on innate, B, and T cell responses against Lachnospiraceae-derived flagellins in health and disease. We discuss the circumstances and immunological mechanisms that underlie these responses, as well as their clinical significance and potential as therapeutic targets.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42331327\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260622215145&amp;v=2.20.0\">42331327<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.100365\">10.1016\/j.mucimm.2026.100365<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 Jun 22:100365. doi: 10.1016\/j.mucimm.2026.100365. Online ahead of print. ABSTRACT Adaptive immune responses, including B and T cell responses, play important roles in establishing and maintaining the mutualistic relationship between the host and intestinal microbiota. Host-microbiota mutualism is disrupted in various immune-mediated inflammatory diseases, including Crohn&#8217;s disease (CD). Aberrant inflammatory memory CD4+ T &#8230; <a title=\"Adaptive immune responses against Lachnospiraceae-derived flagellins and their role in inflammatory bowel disease. Dani\u00eblle M H Barendregt\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/23\/adaptive-immune-responses-against-lachnospiraceae-derived-flagellins-and-their-role-in-inflammatory-bowel-disease-danielle-m-h-barendregt\/\" aria-label=\"Read more about Adaptive immune responses against Lachnospiraceae-derived flagellins and their role in inflammatory bowel disease. Dani\u00eblle M H Barendregt\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-68066","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/68066","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=68066"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/68066\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=68066"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=68066"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=68066"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}