{"id":68433,"date":"2026-06-25T19:08:17","date_gmt":"2026-06-25T17:08:17","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/06\/25\/differences-in-the-cell-wall-architecture-drive-strain-specific-iga-induction-by-limosilactobacillus-reuteriran-lu-on-25-de-june-de-2026-at-1000\/"},"modified":"2026-06-25T19:08:17","modified_gmt":"2026-06-25T17:08:17","slug":"differences-in-the-cell-wall-architecture-drive-strain-specific-iga-induction-by-limosilactobacillus-reuteriran-lu-on-25-de-june-de-2026-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/06\/25\/differences-in-the-cell-wall-architecture-drive-strain-specific-iga-induction-by-limosilactobacillus-reuteriran-lu-on-25-de-june-de-2026-at-1000\/","title":{"rendered":"Differences in the cell-wall architecture drive strain-specific IgA induction by Limosilactobacillus reuteri\u200bRan Lu   on 25 de June de 2026 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2026 Jun 25:qiag088. doi: 10.1093\/jleuko\/qiag088. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Limosilactobacillus reuteri (formerly Lactobacillus reuteri) is a well-studied commensal bacterium known for various health benefits. Our recent findings reveal that the human-derived strain L. reuteri CF48-3A enhances endogenous neonatal immunoglobulin A (IgA) production in mice. In a comparative analysis between the human isolates CF48-3A and PTA-6475, we observed that only CF48-3A induces splenocyte IgA production in vitro, highlighting strain-specific functional diversity within L. reuteri. Further study revealed that the two strains modulate B cell IgA production through distinct mechanisms, largely due to differences in surface proteins and activation of Toll-like receptor 2 (TLR2). While CF48-3A promotes IgA+ plasmablast differentiation and proliferation, PTA-6475 fails to promote antibody-secreting cell populations and does not induce IgA. This latter phenotype was traced to differences in the cell surface architecture. A derivative of PTA-6475 in which eight genes encoding cell surface proteins were inactivated (L. reuteri VPL4366) gained the function to promote plasmablast differentiation and IgA induction. Additionally, IgA induction by CF48-3A and L. reuteri VPL4366 appears to occur, at least partially, via TLR2 signaling, and is not associated with B lymphocyte stimulator (BLyS) or TGF-\u03b2 signaling. These in vitro findings emphasize the strain-specific cell wall architecture plausibly impacts L. reuteri on IgA induction and suggest unique mechanisms by which L. reuteri strains influence B cell differentiation.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42345455\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20260625130817&amp;v=2.20.0\">42345455<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiag088\">10.1093\/jleuko\/qiag088<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2026 Jun 25:qiag088. doi: 10.1093\/jleuko\/qiag088. Online ahead of print. ABSTRACT Limosilactobacillus reuteri (formerly Lactobacillus reuteri) is a well-studied commensal bacterium known for various health benefits. Our recent findings reveal that the human-derived strain L. reuteri CF48-3A enhances endogenous neonatal immunoglobulin A (IgA) production in mice. In a comparative analysis between the human &#8230; <a title=\"Differences in the cell-wall architecture drive strain-specific IgA induction by Limosilactobacillus reuteri\u200bRan Lu   on 25 de June de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/25\/differences-in-the-cell-wall-architecture-drive-strain-specific-iga-induction-by-limosilactobacillus-reuteriran-lu-on-25-de-june-de-2026-at-1000\/\" aria-label=\"Read more about Differences in the cell-wall architecture drive strain-specific IgA induction by Limosilactobacillus reuteri\u200bRan Lu   on 25 de June de 2026 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-68433","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/68433","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=68433"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/68433\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=68433"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=68433"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=68433"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}