{"id":68485,"date":"2026-06-26T07:20:58","date_gmt":"2026-06-26T05:20:58","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/adp-ribosylation-factor-1-sustains-regulatory-t-cell-function-and-mucosal-immune-homeostasis-in-ulcerative-colitis-hua-hua-liu\/"},"modified":"2026-06-26T07:20:58","modified_gmt":"2026-06-26T05:20:58","slug":"adp-ribosylation-factor-1-sustains-regulatory-t-cell-function-and-mucosal-immune-homeostasis-in-ulcerative-colitis-hua-hua-liu","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/adp-ribosylation-factor-1-sustains-regulatory-t-cell-function-and-mucosal-immune-homeostasis-in-ulcerative-colitis-hua-hua-liu\/","title":{"rendered":"ADP-ribosylation factor 1 sustains regulatory T cell function and mucosal immune homeostasis in ulcerative colitis. Hua-Hua Liu"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 Jun 25:100368. doi: 10.1016\/j.mucimm.2026.100368. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Dysregulation of regulatory T cells (Tregs) is a hallmark of immune imbalance in ulcerative colitis (UC), in which their suppressive function relies heavily on post-translational modifications and the stabilization of the transcription factor Foxp3. However, the upstream regulatory mechanisms remain poorly understood. Here, we identify ADP-ribosylation factor 1 (Arf1) as a key regulator of Treg function. Clinical samples from UC patients revealed an inverse correlation between ARF1 expression in Tregs and disease severity. Using a Treg-specific Arf1 knockout mouse model, we demonstrate that Arf1 deficiency impairs induced Treg (iTreg) differentiation, disrupts suppressive function, and aggravates T cell transfer-induced colitis. Mechanistically, Arf1 sustains mitochondrial integrity and represses histone deacetylase 9 (Hdac9), thereby enhancing FOXP3 acetylation and protein stability. These findings establish Arf1 as a critical upstream modulator of Treg cell function and intestinal immune homeostasis, and highlight the ARF1-HDAC9-FOXP3 axis as a promising target for Treg-based therapeutic strategies in UC.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42349655\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260626012057&amp;v=2.20.0\">42349655<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.100368\">10.1016\/j.mucimm.2026.100368<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 Jun 25:100368. doi: 10.1016\/j.mucimm.2026.100368. Online ahead of print. ABSTRACT Dysregulation of regulatory T cells (Tregs) is a hallmark of immune imbalance in ulcerative colitis (UC), in which their suppressive function relies heavily on post-translational modifications and the stabilization of the transcription factor Foxp3. However, the upstream regulatory mechanisms remain poorly understood. Here, &#8230; <a title=\"ADP-ribosylation factor 1 sustains regulatory T cell function and mucosal immune homeostasis in ulcerative colitis. Hua-Hua Liu\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/adp-ribosylation-factor-1-sustains-regulatory-t-cell-function-and-mucosal-immune-homeostasis-in-ulcerative-colitis-hua-hua-liu\/\" aria-label=\"Read more about ADP-ribosylation factor 1 sustains regulatory T cell function and mucosal immune homeostasis in ulcerative colitis. Hua-Hua Liu\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-68485","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/68485","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=68485"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/68485\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=68485"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=68485"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=68485"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}