{"id":68486,"date":"2026-06-26T07:20:59","date_gmt":"2026-06-26T05:20:59","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/mitochondrial-ca2-signaling-a-metabolic-rheostat-defining-tumor-and-immune-cell-fate-amelie-e-bura\/"},"modified":"2026-06-26T07:20:59","modified_gmt":"2026-06-26T05:20:59","slug":"mitochondrial-ca2-signaling-a-metabolic-rheostat-defining-tumor-and-immune-cell-fate-amelie-e-bura","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/mitochondrial-ca2-signaling-a-metabolic-rheostat-defining-tumor-and-immune-cell-fate-amelie-e-bura\/","title":{"rendered":"Mitochondrial Ca2+ signaling: A metabolic rheostat defining tumor and immune cell fate. Am\u00e9lie E Bura"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2026 Jun 25:S1471-4906(26)00137-7. doi: 10.1016\/j.it.2026.05.012. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Mitochondrial calcium (mtCa<sup>2+<\/sup>) has long been framed as a bioenergetic regulator, yet evidence redefines it as a relevant immunometabolic switch. Within the tumor microenvironment, the mitochondrial calcium uniporter (MCU) complex and the NCLX-TMEM65 efflux axis maintain a &#8216;Goldilocks zone&#8217; of Ca<sup>2+<\/sup> homeostasis. This can be exploited by cancer cells to sustain oxidative phosphorylation and tricarboxylic acid-derived oncometabolite production, including succinate, fumarate, and 2-hydroxyglutarate, while imposing ionic and nutrient constraints on infiltrating immune cells. Chronic mtCa<sup>2+<\/sup> overload in effector T cells drives mitochondrial dysfunction and exhaustion, while oxidative phosphorylation-dependent Ca<sup>2+<\/sup> flux enforces the acquisition of an immunosuppressive profile in macrophages. Disrupting these tumor-immune ionic imbalances through selective MCU modulation or efflux pathway targeting offers a strategy to restore immune surveillance and\/or enhance immune checkpoint inhibitor therapies.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42350246\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20260626012058&amp;v=2.20.0\">42350246<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2026.05.012\">10.1016\/j.it.2026.05.012<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2026 Jun 25:S1471-4906(26)00137-7. doi: 10.1016\/j.it.2026.05.012. Online ahead of print. ABSTRACT Mitochondrial calcium (mtCa2+) has long been framed as a bioenergetic regulator, yet evidence redefines it as a relevant immunometabolic switch. Within the tumor microenvironment, the mitochondrial calcium uniporter (MCU) complex and the NCLX-TMEM65 efflux axis maintain a &#8216;Goldilocks zone&#8217; of Ca2+ homeostasis. This &#8230; <a title=\"Mitochondrial Ca2+ signaling: A metabolic rheostat defining tumor and immune cell fate. Am\u00e9lie E Bura\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/mitochondrial-ca2-signaling-a-metabolic-rheostat-defining-tumor-and-immune-cell-fate-amelie-e-bura\/\" aria-label=\"Read more about Mitochondrial Ca2+ signaling: A metabolic rheostat defining tumor and immune cell fate. Am\u00e9lie E Bura\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-68486","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/68486","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=68486"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/68486\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=68486"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=68486"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=68486"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}