{"id":68565,"date":"2026-06-26T13:26:13","date_gmt":"2026-06-26T11:26:13","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/sialylation-modulates-basophil-responsiveness-to-galectin-3-dependent-activationlaurent-ehrlich-on-26-de-june-de-2026-at-1000\/"},"modified":"2026-06-26T13:26:13","modified_gmt":"2026-06-26T11:26:13","slug":"sialylation-modulates-basophil-responsiveness-to-galectin-3-dependent-activationlaurent-ehrlich-on-26-de-june-de-2026-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/sialylation-modulates-basophil-responsiveness-to-galectin-3-dependent-activationlaurent-ehrlich-on-26-de-june-de-2026-at-1000\/","title":{"rendered":"Sialylation Modulates Basophil Responsiveness to Galectin-3-dependent Activation\u200bLaurent Ehrlich   on 26 de June de 2026 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2026 Jun 26:qiag087. doi: 10.1093\/jleuko\/qiag087. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Basophils secrete histamine and IL-4\/13 when co-cultured with human lung adenocarcinoma cells (A549 cells). Previous studies have revealed that this interaction is dependent on Galectin-3 expression on the surface of A549 cells (EC-Gal-3), IgE present on the surface of IL-3 primed basophils, and direct physical interaction between the two cell types, indicating a cognate interaction between IgE and Gal-3. Reciprocal secretion of pro-tumorigenic cytokines (IL-6\/VEGF-A) from A549 cells also results. Here, we further define the biological parameters required for this mode of activation. EC-Gal-3 stimulus has \u223c 20-fold less IgE cross-linking capacity compared with standard anti-IgE. The capacity of IgE-bearing basophils to elicit an EC-Gal-3-mediated response correlates with their responsiveness to standard anti-IgE stimulation, which is known to vary widely among individuals. However, unlike standard anti-IgE stimulation, basophil releasability in response to EC-Gal-3 is influenced by glycosylation patterns on surface-bound IgE. Specifically, bulk sialylation on IgE molecules suppress cellular releasability. Whole cell basophil sialylation also suppresses EC-Gal-3 mediated activation. Gal-3 is an endogenous lectin with multivalent binding capacity and is implicated in a range of diseases involving immune modulation, organ fibrosis, and tumor metastasis. These results can help identify specific physiological and pathophysiological conditions by which IgE:Gal-3 interactions help drive disease processes including wound healing, cancer, and fibrosis, including that which occurs in asthma.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42359483\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20260626072613&amp;v=2.20.0\">42359483<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiag087\">10.1093\/jleuko\/qiag087<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2026 Jun 26:qiag087. doi: 10.1093\/jleuko\/qiag087. Online ahead of print. ABSTRACT Basophils secrete histamine and IL-4\/13 when co-cultured with human lung adenocarcinoma cells (A549 cells). Previous studies have revealed that this interaction is dependent on Galectin-3 expression on the surface of A549 cells (EC-Gal-3), IgE present on the surface of IL-3 primed basophils, &#8230; <a title=\"Sialylation Modulates Basophil Responsiveness to Galectin-3-dependent Activation\u200bLaurent Ehrlich   on 26 de June de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/sialylation-modulates-basophil-responsiveness-to-galectin-3-dependent-activationlaurent-ehrlich-on-26-de-june-de-2026-at-1000\/\" aria-label=\"Read more about Sialylation Modulates Basophil Responsiveness to Galectin-3-dependent Activation\u200bLaurent Ehrlich   on 26 de June de 2026 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-68565","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/68565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=68565"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/68565\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=68565"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=68565"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=68565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}