{"id":68612,"date":"2026-06-28T01:03:24","date_gmt":"2026-06-27T23:03:24","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/germinal-center-responses-at-barrier-organ-sites\/"},"modified":"2026-06-28T01:03:24","modified_gmt":"2026-06-27T23:03:24","slug":"germinal-center-responses-at-barrier-organ-sites","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/germinal-center-responses-at-barrier-organ-sites\/","title":{"rendered":"Germinal center responses at barrier organ sites"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2026 Jun 27;101:102807. doi: 10.1016\/j.coi.2026.102807. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>In this review, we detail the features of barrier germinal centers (GC) that form in tertiary lymphoid structures (TLSs) within non-immune organs that host a local microbiome, and posit a framework of immunity where TLS-GCs created at barrier sites are a key part of normal humoral immunity, and that they form the first layer of an intended multi-layered and increasingly defensive adaptive immune system, providing complementary tissue-specific responses, alongside the local secondary lymphoid organ network and systemic immune responses.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42364257\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20260627190323&amp;v=2.20.0\">42364257<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2026.102807\">10.1016\/j.coi.2026.102807<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2026 Jun 27;101:102807. doi: 10.1016\/j.coi.2026.102807. Online ahead of print. ABSTRACT In this review, we detail the features of barrier germinal centers (GC) that form in tertiary lymphoid structures (TLSs) within non-immune organs that host a local microbiome, and posit a framework of immunity where TLS-GCs created at barrier sites are a key &#8230; <a title=\"Germinal center responses at barrier organ sites\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/germinal-center-responses-at-barrier-organ-sites\/\" aria-label=\"Read more about Germinal center responses at barrier organ sites\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-68612","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/68612","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=68612"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/68612\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=68612"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=68612"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=68612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}