{"id":68707,"date":"2026-06-30T01:00:34","date_gmt":"2026-06-29T23:00:34","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/a-blind-spot-of-human-t-cell-immunology-epitope-specificity-in-secondary-lymphoid-organs\/"},"modified":"2026-06-30T01:00:34","modified_gmt":"2026-06-29T23:00:34","slug":"a-blind-spot-of-human-t-cell-immunology-epitope-specificity-in-secondary-lymphoid-organs","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/a-blind-spot-of-human-t-cell-immunology-epitope-specificity-in-secondary-lymphoid-organs\/","title":{"rendered":"A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2026 Jun 29;101:102809. doi: 10.1016\/j.coi.2026.102809. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The fate of T cells is determined through the expression of a unique T cell receptor (TCR). TCR epitope specificity drives spatial localization, phenotypic and metabolic plasticity, effector function, as well as the evolution of complex repertoires of T cell clones. However, human immunology is often restricted to the peripheral blood compartment and neglects &#8216;professional&#8217; lymphoid organs. Furthermore, despite the generation of single-cell &#8216;atlases&#8217;, our knowledge of the epitopes that are recognized by human T cells is largely limited to only a handful of antigenic specificities from conventionally studied viruses. So far, this has prevented a holistic understanding of T cell clonotypes that link location-dependent cellular qualities to specific antigen exposures or disease entities. Novel methodologies for high-throughput annotation of T cell epitope specificity and high-resolution mapping of histological context bear the potential to enhance our understanding of basic human T cell biology, to provide a large-scale data resource for the connected field of computational T cell biology, and to facilitate the development of novel or improved vaccines and other immunotherapies.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42372370\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20260629190033&amp;v=2.20.0\">42372370<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2026.102809\">10.1016\/j.coi.2026.102809<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2026 Jun 29;101:102809. doi: 10.1016\/j.coi.2026.102809. Online ahead of print. ABSTRACT The fate of T cells is determined through the expression of a unique T cell receptor (TCR). TCR epitope specificity drives spatial localization, phenotypic and metabolic plasticity, effector function, as well as the evolution of complex repertoires of T cell clones. However, &#8230; <a title=\"A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/a-blind-spot-of-human-t-cell-immunology-epitope-specificity-in-secondary-lymphoid-organs\/\" aria-label=\"Read more about A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-68707","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/68707","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=68707"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/68707\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=68707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=68707"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=68707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}