{"id":69122,"date":"2026-07-02T18:58:10","date_gmt":"2026-07-02T16:58:10","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/07\/02\/vista-neutrophils-contribute-to-platinum-resistance-by-suppressing-cd8t-cells-in-high-grade-serous-ovarian-cancer\/"},"modified":"2026-07-02T18:58:10","modified_gmt":"2026-07-02T16:58:10","slug":"vista-neutrophils-contribute-to-platinum-resistance-by-suppressing-cd8t-cells-in-high-grade-serous-ovarian-cancer","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/07\/02\/vista-neutrophils-contribute-to-platinum-resistance-by-suppressing-cd8t-cells-in-high-grade-serous-ovarian-cancer\/","title":{"rendered":"VISTA+ neutrophils contribute to platinum resistance by suppressing CD8+T cells in high-grade serous ovarian cancer"},"content":{"rendered":"<div>\n<p><b>Cancer Immunol Res<\/b>. 2026 Jul 2. doi: 10.1158\/2326-6066.CIR-25-1118. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Elevated neutrophil-to-lymphocyte ratio (NLR) has been associated with platinum resistance and poor outcomes in high-grade serous ovarian cancer (HGSOC), but the biological basis of this association remains unclear. We retrospectively analyzed 434 patients with HGSOC treated with platinum-based chemotherapy and found that elevated NLR was an independent predictor of platinum resistance. To further investigate the cellular basis of this association, we performed immunohistochemistry, proteomic profiling, and single-cell RNA sequencing on patient samples. These analyses identified a distinct subpopulation of V-domain immunoglobulin suppressor of T cell activation-positive neutrophils (VISTA\u207aNeus) enriched in resistant tumors. High VISTA\u207aNeus density was linked to shorter progression-free survival and showed greater predictive value for resistance than total neutrophils. Spatial and multicolor immunohistochemistry analyses further showed that VISTA\u207aNeus were associated with reduced CD8\u207aT-cell infiltration and cytotoxic features. Functional validation in an immunocompetent mouse model showed that anti-VISTA plus cisplatin reduced tumor growth, decreased neutrophil abundance, and increased CD8\u207aT-cell infiltration and granzyme B expression. CD8\u207a T-cell depletion markedly attenuated the therapeutic benefit of the combination. These findings support VISTA\u207aNeus as a potential immunosuppressive neutrophil subset associated with platinum resistance and CD8\u207aT-cell suppression in HGSOC, and support further investigation of VISTA-targeted strategies and the potential biomarker value of VISTA\u207aNeus.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42390478\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101614637&amp;ff=20260702125810&amp;v=2.20.0\">42390478<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1158\/2326-6066.CIR-25-1118\">10.1158\/2326-6066.CIR-25-1118<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Cancer Immunol Res. 2026 Jul 2. doi: 10.1158\/2326-6066.CIR-25-1118. Online ahead of print. ABSTRACT Elevated neutrophil-to-lymphocyte ratio (NLR) has been associated with platinum resistance and poor outcomes in high-grade serous ovarian cancer (HGSOC), but the biological basis of this association remains unclear. We retrospectively analyzed 434 patients with HGSOC treated with platinum-based chemotherapy and found that &#8230; <a title=\"VISTA+ neutrophils contribute to platinum resistance by suppressing CD8+T cells in high-grade serous ovarian cancer\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/02\/vista-neutrophils-contribute-to-platinum-resistance-by-suppressing-cd8t-cells-in-high-grade-serous-ovarian-cancer\/\" aria-label=\"Read more about VISTA+ neutrophils contribute to platinum resistance by suppressing CD8+T cells in high-grade serous ovarian cancer\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[55,42],"tags":[],"class_list":["post-69122","post","type-post","status-publish","format-standard","hentry","category-cancer-immunology-reserch","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/69122","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=69122"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/69122\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=69122"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=69122"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=69122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}