{"id":69134,"date":"2026-07-03T01:03:00","date_gmt":"2026-07-02T23:03:00","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/increased-nur77-is-disconnected-from-tcr-affinity-in-insulin-specific-tregs\/"},"modified":"2026-07-03T01:03:00","modified_gmt":"2026-07-02T23:03:00","slug":"increased-nur77-is-disconnected-from-tcr-affinity-in-insulin-specific-tregs","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/increased-nur77-is-disconnected-from-tcr-affinity-in-insulin-specific-tregs\/","title":{"rendered":"Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Jun 7;215(6):vkag136. doi: 10.1093\/jimmun\/vkag136.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Foxp3+ regulatory T cells (Tregs) are capable suppressors of aberrant self-reactivity. However, how differences in affinity and specificity may support Treg function compared with autoimmune T cell function remains unresolved. In this study, we analyzed the T cell receptor (TCR) repertoires of the regulatory and effector T cells that spontaneously infiltrate pancreatic islets of nonobese diabetic mice and therefore share antigen specificity. Using 2-dimensional micropipette measurements of TCR affinity, we show that effector and regulatory T cell-derived TCRs possess similar wide-ranging affinities for self-antigen. Treg-derived TCRs conferred variable protective function and Treg suppressive capacity was, in part, determined by the relative antigen-reactivity of effector T cells. Interestingly, when expressing the same TCR, Tregs showed higher Nur77-GFP expression than effector T cells in vivo, suggesting a Treg-intrinsic ability to compete for antigen. In vitro, we observed accelerated Treg TCR activation, suggesting that Tregs are poised for faster response to antigen than T effectors. Our findings expose a subpopulation of Tregs possessing low-affinity, suboptimal TCRs, obscured by apparent higher Nur77 expression in Tregs as a whole.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42391331\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260702190259&amp;v=2.20.0\">42391331<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag136\">10.1093\/jimmun\/vkag136<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Jun 7;215(6):vkag136. doi: 10.1093\/jimmun\/vkag136. ABSTRACT Foxp3+ regulatory T cells (Tregs) are capable suppressors of aberrant self-reactivity. However, how differences in affinity and specificity may support Treg function compared with autoimmune T cell function remains unresolved. In this study, we analyzed the T cell receptor (TCR) repertoires of the regulatory and effector T &#8230; <a title=\"Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/increased-nur77-is-disconnected-from-tcr-affinity-in-insulin-specific-tregs\/\" aria-label=\"Read more about Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-69134","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/69134","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=69134"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/69134\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=69134"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=69134"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=69134"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}