{"id":69342,"date":"2026-07-07T01:23:27","date_gmt":"2026-07-06T23:23:27","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/07\/07\/the-scaffolding-protein-akap79-150-shapes-innate-immune-responses-to-allergen\/"},"modified":"2026-07-07T01:23:27","modified_gmt":"2026-07-06T23:23:27","slug":"the-scaffolding-protein-akap79-150-shapes-innate-immune-responses-to-allergen","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/07\/07\/the-scaffolding-protein-akap79-150-shapes-innate-immune-responses-to-allergen\/","title":{"rendered":"The scaffolding protein AKAP79\/150 shapes innate immune responses to allergen"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Jun 7;215(6):vkag115. doi: 10.1093\/jimmun\/vkag115.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Inhalation of house dust mite-derived allergens is a major factor leading to the development of asthma both in children and adults. Allergens stimulate Ca2+-dependent pro-inflammatory cytokine and chemokine gene expression through the opening of ORAI1 Ca2+ channels in the surface membrane of various immune cell-types within the lung. ORAI1 participates in a signalosome with the scaffolding protein A-kinase anchoring protein (AKAP)79\/150 (encoded by the Akap5 gene), which binds numerous protein kinases, calcineurin and transcription factors required for cytokine expression. However, the role of AKAP79\/150 in immune cell activation and the development of airway inflammation in response to allergens has not been established. We found that AKAP79\/150 is expressed in mast cells and macrophages, where it has a pivotal role in driving pro-inflammatory cytokine production in response to house dust mite challenge. By contrast, AKAP79\/150 expression in T cells was low and had little impact on cytokine release following T cell activation. Akap5-\/- mice exhibited significantly reduced type 2 inflammation in the lungs following HDM exposure compared with wild-type controls. Our data demonstrate that AKAP79\/150 is an important co-ordinator of inflammation within the lung in response to airborne allergens, through actions primarily on cells of the innate immune system.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42406837\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260706192326&amp;v=2.20.0\">42406837<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag115\">10.1093\/jimmun\/vkag115<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Jun 7;215(6):vkag115. doi: 10.1093\/jimmun\/vkag115. ABSTRACT Inhalation of house dust mite-derived allergens is a major factor leading to the development of asthma both in children and adults. Allergens stimulate Ca2+-dependent pro-inflammatory cytokine and chemokine gene expression through the opening of ORAI1 Ca2+ channels in the surface membrane of various immune cell-types within the &#8230; <a title=\"The scaffolding protein AKAP79\/150 shapes innate immune responses to allergen\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/07\/the-scaffolding-protein-akap79-150-shapes-innate-immune-responses-to-allergen\/\" aria-label=\"Read more about The scaffolding protein AKAP79\/150 shapes innate immune responses to allergen\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-69342","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/69342","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=69342"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/69342\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=69342"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=69342"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=69342"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}