{"id":69537,"date":"2026-07-09T07:07:17","date_gmt":"2026-07-09T05:07:17","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/inhba-is-transcriptionally-regulated-by-foxa1-through-the-pi3k-akt-signal-pathway-in-acute-lung-injury\/"},"modified":"2026-07-09T07:07:17","modified_gmt":"2026-07-09T05:07:17","slug":"inhba-is-transcriptionally-regulated-by-foxa1-through-the-pi3k-akt-signal-pathway-in-acute-lung-injury","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/inhba-is-transcriptionally-regulated-by-foxa1-through-the-pi3k-akt-signal-pathway-in-acute-lung-injury\/","title":{"rendered":"Inhba is transcriptionally regulated by Foxa1 through the PI3K\/AKT signal pathway in acute lung injury"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Jun 7;215(6):vkag140. doi: 10.1093\/jimmun\/vkag140.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Acute lung injury (ALI) is a fulminant respiratory failure syndrome with no targeted therapy. We show that Inhba is sharply upregulated in the damaged lung tissue of mice and in BEAS-2B cells, and its abundance tracks with cytokine storm and reactive oxygen species (ROS). Mechanistically, AKT activation is associated with increased FOXA1 phosphorylation and abundance, which transcriptionally induce INHBA; this upregulation of INHBA is a key upstream driver of enhanced ROS production and cytokine release in experimental ALI. Genetic deletion or pharmacologic blockade of PI3K\/AKT simultaneously lowered Foxa1 and Inhba, reduced TNF-\u03b1, IL-6, and ROS, and improved histologic injury scores and oxygenation. These findings establish the PI3K\/AKT-Foxa1-Inhba axis as a central driver in experimental ALI models and support its potential as a druggable target for future investigation. Further validation in human ALI samples will be required to support clinical translation.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42419961\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260709010715&amp;v=2.20.0\">42419961<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag140\">10.1093\/jimmun\/vkag140<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Jun 7;215(6):vkag140. doi: 10.1093\/jimmun\/vkag140. ABSTRACT Acute lung injury (ALI) is a fulminant respiratory failure syndrome with no targeted therapy. We show that Inhba is sharply upregulated in the damaged lung tissue of mice and in BEAS-2B cells, and its abundance tracks with cytokine storm and reactive oxygen species (ROS). Mechanistically, AKT activation &#8230; <a title=\"Inhba is transcriptionally regulated by Foxa1 through the PI3K\/AKT signal pathway in acute lung injury\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/inhba-is-transcriptionally-regulated-by-foxa1-through-the-pi3k-akt-signal-pathway-in-acute-lung-injury\/\" aria-label=\"Read more about Inhba is transcriptionally regulated by Foxa1 through the PI3K\/AKT signal pathway in acute lung injury\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-69537","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/69537","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=69537"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/69537\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=69537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=69537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=69537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}