{"id":69538,"date":"2026-07-09T07:07:17","date_gmt":"2026-07-09T05:07:17","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/differential-stem-like-potential-of-naive-and-memory-cd8-t-cells-after-chronic-infection\/"},"modified":"2026-07-09T07:07:17","modified_gmt":"2026-07-09T05:07:17","slug":"differential-stem-like-potential-of-naive-and-memory-cd8-t-cells-after-chronic-infection","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/differential-stem-like-potential-of-naive-and-memory-cd8-t-cells-after-chronic-infection\/","title":{"rendered":"Differential stem-like potential of na\u00efve and memory CD8 T cells after chronic infection"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Jun 7;215(6):vkag164. doi: 10.1093\/jimmun\/vkag164.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Memory CD8 T cells respond rapidly upon antigen re-encounter and are considered advantageous for protective immunity. However, they undergo a swift decline under chronic antigen stimulation. In this study, we found that memory CD8 T cells&#8217; heightened activation sensitivity promotes terminal differentiation and impairs the formation of CXCR5+Tim-3- progenitor subsets, resulting in reduced persistence. This defect was commonly observed in memory CD8 T cells generated by diverse immunization strategies. Mechanistically, their inability to generate progenitor cells was not due to insufficient expression of TCF1 or TOX upregulation. Importantly, blockade of type I interferon signaling during priming restored progenitor differentiation of secondary activated CD8 T cells. These findings highlight that the activation context of memory CD8 T cells critically influences their fate during persistent infection and suggest that modulating inflammatory signals may enhance the durability of secondary responses.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42419960\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260709010715&amp;v=2.20.0\">42419960<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag164\">10.1093\/jimmun\/vkag164<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Jun 7;215(6):vkag164. doi: 10.1093\/jimmun\/vkag164. ABSTRACT Memory CD8 T cells respond rapidly upon antigen re-encounter and are considered advantageous for protective immunity. However, they undergo a swift decline under chronic antigen stimulation. In this study, we found that memory CD8 T cells&#8217; heightened activation sensitivity promotes terminal differentiation and impairs the formation of &#8230; <a title=\"Differential stem-like potential of na\u00efve and memory CD8 T cells after chronic infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/differential-stem-like-potential-of-naive-and-memory-cd8-t-cells-after-chronic-infection\/\" aria-label=\"Read more about Differential stem-like potential of na\u00efve and memory CD8 T cells after chronic infection\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-69538","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/69538","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=69538"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/69538\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=69538"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=69538"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=69538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}