{"id":69759,"date":"2026-07-12T07:06:55","date_gmt":"2026-07-12T05:06:55","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/07\/12\/modeling-pathogenic-b-cell-function-in-experimental-autoimmune-encephalomyelitis\/"},"modified":"2026-07-12T07:06:55","modified_gmt":"2026-07-12T05:06:55","slug":"modeling-pathogenic-b-cell-function-in-experimental-autoimmune-encephalomyelitis","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/07\/12\/modeling-pathogenic-b-cell-function-in-experimental-autoimmune-encephalomyelitis\/","title":{"rendered":"Modeling pathogenic B cell function in experimental autoimmune encephalomyelitis"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Jul 10;215(7):vkag163. doi: 10.1093\/jimmun\/vkag163.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Success of B cell depletion therapy in multiple sclerosis (MS), an immune-mediated demyelinating disease of the central nervous system, places B cells and their functions center stage in efforts to fully understand pathogenesis. Historically, MS animal models of experimental autoimmune encephalomyelitis have featured B cell-independent disease driven by CD4 T cells activated against central nervous system myelin protein epitopes and have provided many insights into autoreactive T cell biology in the context of neuroinflammation and demyelination. Meanwhile, B cells&#8217; growing significance in MS necessitated the development of B cell-dependent experimental autoimmune encephalomyelitis models, which have allowed for critical exploration into pathogenic B cell functions during immune-mediated demyelinating disease, including cytokine and antibody production, as well as antigen presentation to autoreactive CD4 T cells. These advances represent an important arena for investigating MS pathogenesis. In this review, we summarize the various approaches taken to engage pathogenic B cells in animal models of MS.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42435354\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260712010655&amp;v=2.20.0\">42435354<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag163\">10.1093\/jimmun\/vkag163<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Jul 10;215(7):vkag163. doi: 10.1093\/jimmun\/vkag163. ABSTRACT Success of B cell depletion therapy in multiple sclerosis (MS), an immune-mediated demyelinating disease of the central nervous system, places B cells and their functions center stage in efforts to fully understand pathogenesis. Historically, MS animal models of experimental autoimmune encephalomyelitis have featured B cell-independent disease driven &#8230; <a title=\"Modeling pathogenic B cell function in experimental autoimmune encephalomyelitis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/12\/modeling-pathogenic-b-cell-function-in-experimental-autoimmune-encephalomyelitis\/\" aria-label=\"Read more about Modeling pathogenic B cell function in experimental autoimmune encephalomyelitis\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-69759","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/69759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=69759"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/69759\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=69759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=69759"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=69759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}