{"id":69883,"date":"2026-07-14T06:46:47","date_gmt":"2026-07-14T04:46:47","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/07\/14\/whole-body-irradiation-causes-long-term-impairments-in-the-maintenance-and-function-of-naive-cd4-t-cells-specific-for-self-and-non-self-antigens\/"},"modified":"2026-07-14T06:46:47","modified_gmt":"2026-07-14T04:46:47","slug":"whole-body-irradiation-causes-long-term-impairments-in-the-maintenance-and-function-of-naive-cd4-t-cells-specific-for-self-and-non-self-antigens","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/07\/14\/whole-body-irradiation-causes-long-term-impairments-in-the-maintenance-and-function-of-naive-cd4-t-cells-specific-for-self-and-non-self-antigens\/","title":{"rendered":"Whole-body irradiation causes long-term impairments in the maintenance and function of na\u00efve CD4 T cells specific for self- and non-self-antigens"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Jul 10;215(7):vkag174. doi: 10.1093\/jimmun\/vkag174.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Whole-body irradiation (WBI) consistently induces radiation-associated lymphopenia, a complication linked to poor prognosis and reduced overall survival. Understanding the quantitative and qualitative changes in na\u00efve CD4 T cells after WBI is critical because these cells play key roles in both host defense and the propagation of autoimmunity. Here, we show that WBI triggers a rapid decline in the na\u00efve CD4 T-cell pool, followed by thymus-dependent numerical recovery. Shortly after WBI, mice exhibit a reduced frequency of lymphocytic choriomeningitis virus (LCMV) epitope GP66-77-specific na\u00efve CD4 T-cell precursors. Upon infection with LCMV, this reduction leads to delayed effector expansion, impaired memory differentiation, and diminished cytokine production. WBI also disrupts blood-brain barrier (BBB) integrity, enhancing infiltration of GP66-77-specific memory CD4 T cells into the brain and promoting enrichment of brain-resident tissue-resident memory CD4 T cells. Similarly, encephalitogenic MOG38-49-specific CD4 T-cell precursors are reduced after WBI, resulting in delayed but exacerbated experimental autoimmune encephalomyelitis (EAE) compared with nonirradiated controls. WBI-mediated BBB disruption facilitates the entry of encephalitogenic MOG38-49-specific CD4 T cells into the spinal cord, promoting EAE induction and progression even in the absence of pertussis toxin administration. Together, these findings highlight both immune-intrinsic and -extrinsic effects of WBI in shaping na\u00efve CD4 T-cell responses in the context of infection and autoimmunity.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42441427\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260714004647&amp;v=2.20.0\">42441427<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkag174\">10.1093\/jimmun\/vkag174<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Jul 10;215(7):vkag174. doi: 10.1093\/jimmun\/vkag174. ABSTRACT Whole-body irradiation (WBI) consistently induces radiation-associated lymphopenia, a complication linked to poor prognosis and reduced overall survival. Understanding the quantitative and qualitative changes in na\u00efve CD4 T cells after WBI is critical because these cells play key roles in both host defense and the propagation of autoimmunity. &#8230; <a title=\"Whole-body irradiation causes long-term impairments in the maintenance and function of na\u00efve CD4 T cells specific for self- and non-self-antigens\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/14\/whole-body-irradiation-causes-long-term-impairments-in-the-maintenance-and-function-of-naive-cd4-t-cells-specific-for-self-and-non-self-antigens\/\" aria-label=\"Read more about Whole-body irradiation causes long-term impairments in the maintenance and function of na\u00efve CD4 T cells specific for self- and non-self-antigens\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-69883","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/69883","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=69883"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/69883\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=69883"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=69883"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=69883"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}