{"id":70790,"date":"2026-07-17T07:04:50","date_gmt":"2026-07-17T05:04:50","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/gone-but-not-forgotten-lung-infection-history-shapes-future-respiratory-immunity-alicia-dirlam\/"},"modified":"2026-07-17T07:04:50","modified_gmt":"2026-07-17T05:04:50","slug":"gone-but-not-forgotten-lung-infection-history-shapes-future-respiratory-immunity-alicia-dirlam","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/gone-but-not-forgotten-lung-infection-history-shapes-future-respiratory-immunity-alicia-dirlam\/","title":{"rendered":"Gone but not forgotten: lung infection history shapes future respiratory immunity. Alicia Dirlam"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 Jul 16:100386. doi: 10.1016\/j.mucimm.2026.100386. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>After respiratory infection, the lung does not simply return to the prior baseline but adopts a new distinct post-infection steady state involving durable imprints that can shape tissue responses to subsequent challenges. This review introduces the concept of lung tissue memory, whereby prior infection leaves long-term changes across immune and structural compartments, with consequences for tissue repair and disease severity during later, antigenically distinct challenges. Pre-existing and newly emerging cell populations establish networks of cell-cell crosstalk that can initiate and maintain altered cellular states. We discuss to what degree these persistent adaptations reflect shifts in cellular composition, cell-intrinsic reprogramming, changes in inflammatory tone and altered tissue niches. Finally, we propose that infection-experienced models provide a more translationally relevant framework to understand immune networks operating in the lung during infection in humans, and we present how a better understanding of tissue memory informs therapeutic strategies and improved design of antigen-specific and more broadly protective mucosal vaccines.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42462878\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260717010449&amp;v=2.20.0\">42462878<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.100386\">10.1016\/j.mucimm.2026.100386<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 Jul 16:100386. doi: 10.1016\/j.mucimm.2026.100386. Online ahead of print. ABSTRACT After respiratory infection, the lung does not simply return to the prior baseline but adopts a new distinct post-infection steady state involving durable imprints that can shape tissue responses to subsequent challenges. This review introduces the concept of lung tissue memory, whereby prior &#8230; <a title=\"Gone but not forgotten: lung infection history shapes future respiratory immunity. Alicia Dirlam\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/gone-but-not-forgotten-lung-infection-history-shapes-future-respiratory-immunity-alicia-dirlam\/\" aria-label=\"Read more about Gone but not forgotten: lung infection history shapes future respiratory immunity. Alicia Dirlam\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-70790","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/70790","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=70790"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/70790\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=70790"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=70790"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=70790"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}