{"id":71279,"date":"2026-07-23T01:22:02","date_gmt":"2026-07-22T23:22:02","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/07\/23\/calcium-signaling-in-microglial-immune-functions-current-understanding-and-implications-for-disease\/"},"modified":"2026-07-23T01:22:02","modified_gmt":"2026-07-22T23:22:02","slug":"calcium-signaling-in-microglial-immune-functions-current-understanding-and-implications-for-disease","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/07\/23\/calcium-signaling-in-microglial-immune-functions-current-understanding-and-implications-for-disease\/","title":{"rendered":"Calcium signaling in microglial immune functions: current understanding and implications for disease"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2026 Jul 22;102:102819. doi: 10.1016\/j.coi.2026.102819. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Microglia are the resident innate immune cells of the brain that play essential roles in immune surveillance, phagocytosis, and neuroinflammatory responses. A central regulator of these diverse functions is intracellular Ca<sup>2+<\/sup> signaling, which connects extracellular cues to transcriptional and metabolic programs that shape microglial activation states. Recent advances have expanded understanding of the &#8216;Ca<sup>2+<\/sup> toolkit&#8217; in microglia, which includes P2X and P2Y receptors, Orai Ca<sup>2+<\/sup> channels, transient receptor potential channels, inositol triphosphate receptors, and organellar Ca<sup>2+<\/sup> handling systems. These pathways generate dynamic and spatially localized Ca<sup>2+<\/sup> signals that regulate numerous effector functions, including process motility, cytokine production, phagocytosis, metabolism, and communication with other brain cells. Emerging evidence further identifies dysregulated Ca<sup>2+<\/sup> signaling as a key driver of chronic neuroinflammation in brain disorders. Here, we review the major components of the microglial Ca<sup>2+<\/sup> signaling toolkit, discuss their molecular mechanisms and physiological functions, and highlight contributions to neuroinflammatory diseases.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42485732\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20260722192201&amp;v=2.20.0\">42485732<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2026.102819\">10.1016\/j.coi.2026.102819<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2026 Jul 22;102:102819. doi: 10.1016\/j.coi.2026.102819. Online ahead of print. ABSTRACT Microglia are the resident innate immune cells of the brain that play essential roles in immune surveillance, phagocytosis, and neuroinflammatory responses. A central regulator of these diverse functions is intracellular Ca2+ signaling, which connects extracellular cues to transcriptional and metabolic programs that &#8230; <a title=\"Calcium signaling in microglial immune functions: current understanding and implications for disease\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/23\/calcium-signaling-in-microglial-immune-functions-current-understanding-and-implications-for-disease\/\" aria-label=\"Read more about Calcium signaling in microglial immune functions: current understanding and implications for disease\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-71279","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/71279","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=71279"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/71279\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=71279"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=71279"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=71279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}