{"id":71498,"date":"2026-07-26T07:26:05","date_gmt":"2026-07-26T05:26:05","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/07\/26\/beyond-antibodies-emerging-roles-of-b-cells-in-gastrointestinal-inflammation-and-disease-marina-costa-fujishima\/"},"modified":"2026-07-26T07:26:05","modified_gmt":"2026-07-26T05:26:05","slug":"beyond-antibodies-emerging-roles-of-b-cells-in-gastrointestinal-inflammation-and-disease-marina-costa-fujishima","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/07\/26\/beyond-antibodies-emerging-roles-of-b-cells-in-gastrointestinal-inflammation-and-disease-marina-costa-fujishima\/","title":{"rendered":"Beyond antibodies: Emerging roles of B cells in gastrointestinal inflammation and disease. Marina Costa Fujishima"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 Jul 25:100390. doi: 10.1016\/j.mucimm.2026.100390. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>B cells play a crucial role in maintaining immune homeostasis at mucosal surfaces, including those of the gastrointestinal (GI) tract. Perturbed humoral immunity and antibody-mediated functions of B cells are well described in patients with chronic GI inflammatory diseases. However, our understanding of antibody-independent B cell functions such as antigen presentation, immunoregulatory cytokine production and tissue remodeling are more limited. Comprehensively defining the immunobiology of B cells beyond humoral immunity during GI inflammation will improve our ability to develop effective, targeted treatments that modulate B cell pro- versus anti-inflammatory activity in the clinical management of GI inflammatory diseases. In this review, we discuss the emerging roles of B cells using antibody-independent mechanisms to maintain intestinal homeostasis, and how this evolves to B cells becoming active players in immunopathology underlying GI inflammatory conditions and specific GI cancers.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42501823\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260726012605&amp;v=2.20.0\">42501823<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.100390\">10.1016\/j.mucimm.2026.100390<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 Jul 25:100390. doi: 10.1016\/j.mucimm.2026.100390. Online ahead of print. ABSTRACT B cells play a crucial role in maintaining immune homeostasis at mucosal surfaces, including those of the gastrointestinal (GI) tract. Perturbed humoral immunity and antibody-mediated functions of B cells are well described in patients with chronic GI inflammatory diseases. However, our understanding of &#8230; <a title=\"Beyond antibodies: Emerging roles of B cells in gastrointestinal inflammation and disease. Marina Costa Fujishima\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/26\/beyond-antibodies-emerging-roles-of-b-cells-in-gastrointestinal-inflammation-and-disease-marina-costa-fujishima\/\" aria-label=\"Read more about Beyond antibodies: Emerging roles of B cells in gastrointestinal inflammation and disease. Marina Costa Fujishima\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-71498","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/71498","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=71498"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/71498\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=71498"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=71498"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=71498"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}