{"id":71783,"date":"2026-07-30T06:52:41","date_gmt":"2026-07-30T04:52:41","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/07\/30\/the-club-cell-circadian-clock-regulates-temporal-patterns-in-leukocyte-trafficking-in-chronic-allergic-airways-disease-jafar-cain\/"},"modified":"2026-07-30T06:52:41","modified_gmt":"2026-07-30T04:52:41","slug":"the-club-cell-circadian-clock-regulates-temporal-patterns-in-leukocyte-trafficking-in-chronic-allergic-airways-disease-jafar-cain","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/07\/30\/the-club-cell-circadian-clock-regulates-temporal-patterns-in-leukocyte-trafficking-in-chronic-allergic-airways-disease-jafar-cain\/","title":{"rendered":"The club cell circadian clock regulates temporal patterns in leukocyte trafficking in chronic allergic airways disease. Jafar Cain"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 Jul 29:100384. doi: 10.1016\/j.mucimm.2026.100384. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Patients with allergic asthma exhibit distinct temporal variations in symptoms and disease severity, which oscillate across the 24 h day. We have previously shown that the molecular circadian clock plays a critical role in temporally gating the response to allergen challenge in mice. Club cells, a subset of pulmonary bronchial epithelial cells, are implicated in the gating of time-dependent responses to type-1 inflammatory stimuli and trafficking of neutrophils to the lung. Using a club cell specific Bmal1 knockout mouse (CCSP-Bmal1 KO) we found that this is also true in the setting of chronic type-2 pulmonary inflammation, where eosinophil and T-helper 2 cell trafficking patterns were abolished in mice lacking a functional circadian clock within the lung. Notably, we find that circadian patterns in airway permeability are lost in CCSP-Bmal1 KO mice, rendering the barrier equally permissible to trafficking cells at all times of day.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42526761\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260730005240&amp;v=2.20.0.post5+40e1b98\">42526761<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.100384\">10.1016\/j.mucimm.2026.100384<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 Jul 29:100384. doi: 10.1016\/j.mucimm.2026.100384. Online ahead of print. ABSTRACT Patients with allergic asthma exhibit distinct temporal variations in symptoms and disease severity, which oscillate across the 24 h day. We have previously shown that the molecular circadian clock plays a critical role in temporally gating the response to allergen challenge in mice. &#8230; <a title=\"The club cell circadian clock regulates temporal patterns in leukocyte trafficking in chronic allergic airways disease. Jafar Cain\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/30\/the-club-cell-circadian-clock-regulates-temporal-patterns-in-leukocyte-trafficking-in-chronic-allergic-airways-disease-jafar-cain\/\" aria-label=\"Read more about The club cell circadian clock regulates temporal patterns in leukocyte trafficking in chronic allergic airways disease. Jafar Cain\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-71783","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/71783","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=71783"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/71783\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=71783"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=71783"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=71783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}